In Vitro Interactions of Dietary Fibre Enriched Food Ingredients with Primary and Secondary Bile Acids. [PDF]
Nutrients, 2019 Dietary fibres are reported to interact with bile acids, preventing their reabsorption and promoting their excretion into the colon. We used a method based on in vitro digestion, dialysis, and kinetic analysis to investigate how dietary fibre enriched ...
Naumann S +4 more
europepmc +2 more sources
Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids. [PDF]
Microbiome, 2019 The microbiome has been implicated in the initiation and persistence of inflammatory bowel disease. Despite the fact that diet is one of the most potent modulators of microbiome composition and function and that dietary intervention is the first-line ...
Wang S +15 more
europepmc +2 more sources
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. [PDF]
Cell Host & Microbe, 2020 Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in intestinal inflammation, we performed metabolomic, microbiome, metagenomic,
S. Sinha +14 more
semanticscholar +4 more sources
Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived Secondary Bile Acids, and Health Markers in Healthy Adults: A Randomized Controlled Trial. [PDF]
J Nutr, 2018 Background Epidemiologic data suggest that diets rich in nuts have beneficial health effects, including reducing total and cause-specific mortality from cancer and heart disease.
Holscher HD +7 more
europepmc +2 more sources
Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation [PDF]
International Journal of Molecular Sciences, 2018 Hepatic stellate cells (HSCs) are key players in liver fibrosis, cellular senescence, and hepatic carcinogenesis. Bile acids (BAs) are involved in the activation of HSCs, but the detailed mechanism of this process remains unclear.
Kunihiro Saga +13 more
semanticscholar +3 more sources
Secondary bile acids: an underrecognized cause of colon cancer [PDF]
World Journal of Surgical Oncology, 2014 Bile acids were first proposed as carcinogens in 1939. Since then, accumulated evidence has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels of bile acids as an important risk factor for gastrointestinal cancers.
Hana Ajouz, D. Mukherji, A. Shamseddine
semanticscholar +3 more sources
Gut MicrobesExcess amino acids from a protein-rich diet are mainly catabolized in the liver. However, it is still unclear to what extent the gut microbiota may be involved in the mechanisms governing this catabolism.
Sandra Tobón-Cornejo +16 more
doaj +2 more sources
Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis [PDF]
eBioMedicine, 2021 Significantly elevated serum and hepatic bile acid (BA) concentrations have been known to occur in patients with liver fibrosis. However, the roles of different BA species in liver fibrogenesis are not fully understood.We quantitatively measured blood BA concentrations in nonalcoholic steatohepatitis (NASH) patients with liver fibrosis and healthy ...
G. Xie +16 more
semanticscholar +4 more sources
Secondary bile acids inhibit Candida albicans growth and morphogenesis [PDF]
Pathogens and Disease, 2018 Candida albicans is one of the most common causes of fungal infections in humans with a significant mortality rate. However, the factors involved in C. albicans gastrointestinal (GI) colonization remain unclear. We hypothesize that secondary bile acids have direct antifungal activity against C.
Jack Guinan +2 more
semanticscholar +3 more sources
iScience, 2021 Summary: Bile acids are metabolites of cholesterol that facilitate lipid digestion and absorption in the small bowel. Bile acids work as agonists of receptors to regulate their own metabolism.
Tomoki Ota +9 more
doaj +1 more source