Results 31 to 40 of about 323,138 (302)
Bile acids as inflammatory mediators and modulators of intestinal permeability
Frontiers in Immunology, 2022 Bile acids are critical for the digestion and absorption of lipids and fat-soluble vitamins; however, evidence continues to emerge supporting additional roles for bile acids as signaling molecules. After they are synthesized from cholesterol in the liver,
Nathan Calzadilla +9 more
doaj +1 more source
Carcinogenicity of deoxycholate, a secondary bile acid [PDF]
Archives of Toxicology, 2011 High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen.
Bernstein, Carol +6 more
openaire +2 more sources
Fecal Bile Acids and Neutral Sterols Are Associated with Latent Microbial Subgroups in the Human Gut
Metabolites, 2022 Bile acids, neutral sterols, and the gut microbiome are intricately intertwined and each affects human health and metabolism. However, much is still unknown about this relationship. This analysis included 1280 participants of the KORA FF4 study.
Taylor A. Breuninger +10 more
doaj +1 more source
Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]
, 2020 In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco +4 more
core +1 more source
Metabolites, 2022 Bile acids are a key mediator of the molecular microbiome-host interaction, and various mass spectrometry-based assays have been developed in the recent decade to quantify a wide range of bile acids.
Sven-Bastiaan Haange +15 more
doaj +1 more source
Primary and Secondary Bile Acids in Meconium [PDF]
Pediatric Research, 1971 Extract: Meconium, newborn stool, and fetal bile were examined for bile acids by the techniques of gas liquid chromatography, thin layer chromatography and colorimetric spectrometry. Cholic, chenodeoxycholic, deoxycholic, and lithocholic acid were detected in meconium.
Harvey L Sharp +3 more
openaire +1 more source
The Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology
Journal of Lipid Research, 2023 Bile acids are detergents derived from cholesterol that function to solubilize dietary lipids, remove cholesterol from the body, and act as nutrient signaling molecules in numerous tissues with functions in the liver and gut being the best understood ...
Jason M. Ridlon +2 more
doaj +1 more source
Cholestasis impairs gut microbiota development and bile salt hydrolase activity in preterm neonates
Gut Microbes, 2023 Cholestasis refers to impaired bile flow from the liver to the intestine. In neonates, cholestasis causes poor growth and may progress to liver failure and death.
Lauren E. Lynch +7 more
doaj +1 more source
Bile acid-independent protection against Clostridioides difficile infection.
PLoS Pathogens, 2021 Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use.
Andrea Martinez Aguirre +8 more
doaj +1 more source
Profiling of Urinary Glucuronidated Bile Acids across Age Groups
Metabolites, 2022 We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1 ...
Yamato Muto +6 more
doaj +1 more source