Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis [PDF]
International Journal of Cancer, 2017 The gut microbiota plays an important role in maintaining intestinal homeostasis. Dysbiosis is associated with intestinal tumorigenesis. Deoxycholic acid (DCA), a secondary bile acid increased by a western diet, correlates with intestinal carcinogenesis. However, evidence relating bile acids, intestinal microbiota and tumorigenesis are limited.
Hailong Cao +13 more
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mSphere, 2016 It is hypothesized that the depletion of microbial members responsible for converting primary bile acids into secondary bile acids reduces resistance to Clostridium difficile colonization. To date, inhibition of C.
Casey M. Theriot +2 more
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Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles [PDF]
, 2016 Background: The healthy microbiome protects against the development of Clostridium difficile infection (CDI), which typically develops following antibiotics.
Allegretti, J. R. +9 more
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Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice [PDF]
PLOS ONE, 2019 Ursodeoxycholic acid (commercially available as ursodiol) is a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases. Ursodiol can modulate bile acid pools, which have the potential to alter the gut microbiota community structure.
Jenessa A. Winston +4 more
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Biosynthesis and biotransformation of bile acids [PDF]
Hospital Pharmacology, 2017 Bile acids are steroidal compounds, which contain 24 carbon atoms. They can be classified into two major groups: primary and secondary. The most abundant bile acids: The primary bile acids include cholic acid and chenodeoxycholic acid, while the major ...
Šarenac Tanja M., Mikov Momir M.
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The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease. [PDF]
, 2018 BACKGROUND: Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia.
Bao, X +7 more
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Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure [PDF]
Journal of Cardiac Failure, 2017 Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart failure (HF), and microbial metabolism has a major impact on BA homeostasis.
Cristiane C.K. Mayerhofer +9 more
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Archives of Medical Science, 2021 Introduction Infant jaundice is a common condition which results from a high concentration of serum bilirubin. Phototherapy is a widely used treatment for bilirubin clearance.
Kun Zhang +5 more
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Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine [PDF]
, 2019 Background: The upper gastrointestinal tract plays a prominent role in human physiology as the primary site for enzymatic digestion and nutrient absorption, immune sampling, and drug uptake.
Bogatyrev, Said R. +2 more
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Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition. [PDF]
PLoS ONE, 2016 OBJECTIVE:Severe acute malnutrition (SAM) is a major cause of mortality in children under 5 years and is associated with hepatic steatosis. Bile acids are synthesized in the liver and participate in dietary fat digestion, regulation of energy expenditure,
Ling Zhang +10 more
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