Does ursodeoxycholic acid change the proliferation of the colorectal mucosa? A randomized, placebo-controlled study [PDF]
Background: In animal models ursodeoxycholic acid (UDCA) showed a chemoprotective effect against colon cancer. To explain this, a reduced proliferation of the colorectal mucosal proliferation was suggested.
Diebold, J. +6 more
core +1 more source
Consortium of Probiotics Attenuates Colonization of Clostridioides difficile
Clostridioides difficile infection (CDI) is increasing morbidity and mortality rates globally. Fecal microbiota transplantation (FMT), an effective therapy for eliminating Clostridioides difficile (C.
Xianping Li +20 more
doaj +1 more source
Management Letter, Year Ended June 30, 1999 [PDF]
The intestinal microbiome is essential in humans to maintain physiological balance and nutrition metabolism. Laparoscopic cholecystectomy due to gallstone disease and cholecystitis can cause intestinal microbial dysbiosis, and following bile acid ...
Jiawei Geng +9 more
core +4 more sources
Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V +3 more
core +1 more source
Secondary bile acids effects in colon pathology. Experimental mice study [PDF]
To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon.The study used C57BL6 female mice divided into four groups. The control group received a balanced diet and the others received diets supplemented with 0.25% DOC, 0.25% LCA and ...
Saracut, Claudiu +7 more
openaire +5 more sources
Manipulating the Microbiome: An Alternative Treatment for Bile Acid Diarrhoea
Bile acid diarrhoea (BAD) is a widespread gastrointestinal disease that is often misdiagnosed as irritable bowel syndrome and is estimated to affect 1% of the United Kingdom (UK) population alone.
Evette B. M. Hillman +5 more
doaj +1 more source
Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]
Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Abell +59 more
core +1 more source
Bile acids are a risk factor for colorectal cancer [PDF]
Bile acids were first considered carcinogenic in 1939. Since then, accumulated data have associated colon cell changes with high levels of bile acids as an important risk factor for developing colorectal cancer, which is more common among people who ...
L. M. Krumz +4 more
doaj +1 more source
Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Fischer, S. +5 more
core +1 more source
Abnormal metabolism of secondary bile acids in patients with cirrhosis [PDF]
The composition of bile acids in human bile was determined in bile-rich duodenal fluid on four consecutive days in a group of seven patients with cirrhosis and eight control patients with no liver disease. There was a marked reduction of secondary biliary bile acids in cirrhotic patients. Possible mechanisms for these changes are discussed.
Z R, Vlahcevic +3 more
openaire +2 more sources

