Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells. [PDF]
Circ Res, 2023 Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and compartmentalized niches. These niches are optimized to facilitate the encounter of naive lymphocytes with antigens and antigen-presenting cells, enabling optimal generation of adaptive immune responses. Lymphatic vessels of lymphoid organs are uniquely specialized to perform
Arroz-Madeira S +3 more
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Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions [PDF]
Nature Communications, 2018 Fibroblastic reticular cells (FRCs) are important regulators of T cell survival, proliferation, and migration in secondary lymphoid organs, but their role in HIV infection isn’t studied. Here, Murakami et al.
Tomoyuki Murakami +5 more
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Protective fibroblastic niches in secondary lymphoid organs
Journal of Experimental Medicine, 2023 Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to dedicated microenvironmental niches where they provide lymphocytes and myeloid cells with homeostatic growth and differentiation factors.
Angelina De Martin +3 more
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Tertiary lymphoid structure related B-cell IgE isotype switching and secondary lymphoid organ linked IgE production in mouse allergy model [PDF]
BMC Immunology, 2020 Background Numerous data obtained by different research laboratories indicate that specific IgE production is triggered independently of specific IgG or IgA ones and so it is not linked to fully matured germinal centers formation in the secondary ...
Dmitrii Borisovich Chudakov +5 more
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Natural killer cells in skin: a unique opportunity to better characterize the many facets of an overlooked secondary lymphoid organ [PDF]
Frontiers in ImmunologyNatural killer (NK) cells are lymphoid-derived cells that play a critical role in bridging innate and adaptive immunity. Given their ability to recognize and directly kill targets possessing missing or altered self-proteins and to induce indirect killing
Kirsten M. Johnson, Dean A. Lee
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PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice. [PDF]
PLoS ONE, 2019 Recently the anti-viral effects of prophylactic treatment with the low-molecular-weight heparan sulfate mimetic PG545 in Ross River virus (RRV) infected mice were reported.
Aroon Supramaniam +5 more
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Neutrophils in secondary lymphoid organs [PDF]
Immunology, 2021 AbstractNeutrophils are traditionally considered short‐lived, circulating innate immune cells that are rapidly recruited to sites of inflammation in response to infectious and inflammatory stimuli. Neutrophils efficiently internalize, kill or entrap pathogens, but their effector molecules may cause collateral tissue damage.
Lok, Laurence SC, Clatworthy, Menna R
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iHALT unlocks liver functionality as a surrogate secondary lymphoid organ. [PDF]
NatureGridley J +11 more
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Radiology Case Reports, 2022 Marginal zone lymphoma of mucosa-associated lymphoid tissue is a B-cell lymphoma which arises in extranodal sites, most commonly the stomach. Involvement of the breast is very rare.
Cecile D Moliva Anendaga, MD +5 more
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Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells
Frontiers in Immunology, 2022 Regulatory T cells in non-lymphoid tissues are not only critical for maintaining self-tolerance, but are also important for promoting organ homeostasis and tissue repair.
Kathrin L. Braband +9 more
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