Results 91 to 100 of about 38,664 (219)
Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Sex differences are increasingly recognized as central to the biology of Alzheimer's disease (AD), yet the mechanisms through which they shape brain metabolism and disease vulnerability remain incompletely understood. Brain glucose hypometabolism is a core hallmark of AD and emerges decades before clinical decline, but accumulating evidence ...
Marjan Ramezan +4 more
wiley +1 more source
Stress, stress systems, and Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly +5 more
wiley +1 more source
Mapping cross‐domain drivers of Alzheimer's disease risk through integrated network analysis
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder with numerous known risk factors. Identification of which genetic factors are causal drivers is difficult due to the long disease prodrome in an inaccessible organ.
Gregory A Cary +10 more
wiley +1 more source
Unraveling the complexity of γ-secretase
Seminars in Cell & Developmental Biology, 2020 γ-Secretase was initially defined as a proteolytic activity that cleaves within the transmembrane of the amyloid precursor protein (APP) to produce the amyloid β-peptide of Alzheimer's disease. The discovery of mutations in APP and the presenilins associated with familial Alzheimer's disease and their effects on APP processing dovetailed with ...
openaire +3 more sources
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang +5 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug‐development pipelines highlights the limited clinical impact of single‐target therapies and has increased interest in multi‐target approaches acting on shared biological hubs.
Humberto Martínez‐Orozco +4 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Women are increasingly entering the dementia research workforce, but they frequently fail to attain senior leadership positions in academia. Discrepancies in academic research outputs were investigated to guide equity‐focused policy recommendations.
Jayalakshmi Viswanathan +18 more
wiley +1 more source
Dementia etiology classification using NULISA plasma biomarkers and machine learning
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Accurate ante mortem differentiation among dementia etiologies remains challenging, particularly for atypical or mixed clinical presentations. Multiplexed plasma proteomics paired with supervised machine learning offers a minimally invasive and accessible approach for differential diagnosis.
Kelly N. DuBois +9 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Lufuno Mulelu +4 more
wiley +1 more source