Results 101 to 110 of about 86,542 (275)
Journal of Ultrasound in Medicine, EarlyView.Suppurative nevus comedonicus (SNC) is a variant of nevus comedonicus in which the characteristic features coexist with recurrent inflammatory lesions that clinically resemble those of hidradenitis suppurativa (HS). We present the ultrasound characteristics of this entity and emphasize the value of high‐resolution dermatologic ultrasound both as a ...
Marta Ivars +4 more
wiley +1 more source
Neurobiology of Disease, 2003 γ-Secretase is a proteolytic complex whose substrates include Notch, β-amyloid precursor protein (APP), and several other type I transmembrane proteins. Presenilin (PS) and nicastrin are known components of this high-molecular-weight complex, and recent ...
Stephanie Baulac +6 more
doaj +1 more source
LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease. [PDF]
, 2019 The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloidogenic ...
Gordts, Philip LSM +7 more
core +3 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Molecules, 2009 Selective lowering of amyloid-β levels with small-molecule γ-secretase inhibitors is a promising therapeutic approach for Alzheimer’s disease. In this work, we developed a high throughput assay for screening of γ-secretase inhibitors with endogenous γ ...
Lie-Feng Wang, Xin Xie, Ru Zhang
doaj +1 more source
In Silico Structure‐Guided Design of Peptide Candidates Targeting γ‐Secretase Subunit Assembly
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The γ‐secretase complex is a membrane‐embedded protease essential for intramembrane cleavage of substrates such as Notch receptors and the amyloid precursor protein (APP), processes central to cancer progression and Alzheimer's disease (AD) pathology.
Selcen Arı Yuka +2 more
wiley +1 more source
Neurobiology of Disease, 2008 Alzheimer's disease (AD) is characterized by overproduction of Aβ derived from APP cleavage via β- and γ-secretase pathway. Recent evidence has linked altered cholesterol metabolism to AD pathogenesis. In this study, we show that AD brain had significant
Huaqi Xiong +10 more
doaj +1 more source
A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells
Sensors, 2020 Presenilin (PS)/γ-secretase plays a pivotal role in essential cellular events via proteolytic processing of transmembrane proteins that include APP and Notch receptors. However, how PS/γ-secretase activity is spatiotemporally regulated by other molecular
Mei CQ Houser +6 more
doaj +1 more source
Notch3 targeting. A novel weapon against ovarian cancer stem cells [PDF]
, 2019 Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models.
Bellavia, Diana +5 more
core +1 more source
Cell Reports, 2018 Abnormalities of the endolysosomal and autophagy systems are found in Alzheimer's disease, but it is not clear whether defects in these systems are a cause or consequence of degenerative processes in the disease.
Ch Hung, F. J. Livesey
semanticscholar +1 more source