Structure and dynamics of the active Gs-coupled human secretin receptor
Nature Communications, 2020 The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex ...
Maoqing Dong +2 more
exaly +3 more sources
Secretin targets interstitial cells of Cajal to regulate intestinal contractions [PDF]
EMBO ReportsSecretin is a gastrointestinal (GI) hormone that slows intestinal motility, an effect thought to be mediated through vagal afferent pathways. In this study we show evidence for a novel function of secretin involving a non-neural mechanism mediated by ...
Allison M Bartlett +3 more
doaj +2 more sources
Structural insights into the secretin complex of a type IVb pilus system [PDF]
Nature CommunicationsThe bundle-forming pilus (BFP) system in enteropathogenic Escherichia coli (EPEC) produces type IVb pili that enable bacterial auto-aggregation, facilitating bacterial adhesion, colonization, and virulence.
Chenchen Pei +8 more
doaj +2 more sources
MOLECULAR EVOLUTION OF GPCRS: Secretin/secretin receptors [PDF]
Journal of Molecular Endocrinology, 2014 In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic secretion. To date, secretin has only been identified in tetrapods, with the earliest diverged secretin found in frogs.
Chow, BKC, JIN, J, Tam, JKV, Lee, LTO
openaire +5 more sources
Impact of secretin receptor homo-dimerization on natural ligand binding [PDF]
Nature CommunicationsClass B G protein-coupled receptors can form dimeric complexes important for high potency biological effects. Here, we apply pharmacological, biochemical, and biophysical techniques to cells and membranes expressing the prototypic secretin receptor (SecR)
Kaleeckal G. Harikumar +5 more
doaj +2 more sources
PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa [PDF]
Nature CommunicationsType IV pili (T4P) produced by the pathogen Pseudomonas aeruginosa play a pivotal role in adhesion, surface motility, biofilm formation, and infection in humans.
Shuaiqi Guo +5 more
doaj +2 more sources
Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. [PDF]
PLoS ONE, 2011 At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear.
Janice K V Tam +7 more
doaj +1 more source
Molecular Metabolism, 2023 Objective: Obesity is a major global health problem which can be targeted with new mechanistic diverse pharmacological interventions. Here we evaluate a new long-acting secretin receptor agonist as a potential treatment for obesity.
Mona Loeffler +6 more
doaj +1 more source
Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
Frontiers in Endocrinology, 2021 Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic
Sanna Laurila +6 more
doaj +1 more source
The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder
Frontiers in Cellular Neuroscience, 2020 Gut peptide hormones are one group of secretory factors produced from gastrointestinal endocrine cells with potent functions in modulating digestive functions.
Xin-Rui Qi, Li Zhang
doaj +1 more source