Results 1 to 10 of about 28,744 (253)

Secretin targets interstitial cells of Cajal to regulate intestinal contractions [PDF]

EMBO Reports
Secretin is a gastrointestinal (GI) hormone that slows intestinal motility, an effect thought to be mediated through vagal afferent pathways. In this study we show evidence for a novel function of secretin involving a non-neural mechanism mediated by ...
Allison M Bartlett, Peter J Blair, Kenton M Sanders, Salah A Baker   +3 more
doaj   +2 more sources

Structural insights into the secretin complex of a type IVb pilus system [PDF]

Nature Communications
The bundle-forming pilus (BFP) system in enteropathogenic Escherichia coli (EPEC) produces type IVb pili that enable bacterial auto-aggregation, facilitating bacterial adhesion, colonization, and virulence.
Chenchen Pei, Hui Sun, Yinliang Qi, Xiaomei Li, Zhixiong Fang, Manjuan Tang, Rujing Zhang, Zhaofeng Yan, Meng Yin   +8 more
doaj   +2 more sources

Metabolic effects of secretin [PDF]

, 2013
postprin
Chow, BKC, Sekar, R
core   +3 more sources

Impact of secretin receptor homo-dimerization on natural ligand binding [PDF]

Nature Communications
Class B G protein-coupled receptors can form dimeric complexes important for high potency biological effects. Here, we apply pharmacological, biochemical, and biophysical techniques to cells and membranes expressing the prototypic secretin receptor (SecR)
Kaleeckal G. Harikumar, Sarah J. Piper, Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, Laurence J. Miller   +5 more
doaj   +2 more sources

Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis. [PDF]

Cell Prolif
Li Y, Li T, Jin F, Liu S, Xu D, Wei Z, Gao X, Cai W, Mao N, Yang F, Zhang H, Shi Y, Xu H.   +12 more
europepmc   +3 more sources

PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa [PDF]

Nature Communications
Type IV pili (T4P) produced by the pathogen Pseudomonas aeruginosa play a pivotal role in adhesion, surface motility, biofilm formation, and infection in humans.
Shuaiqi Guo, Yunjie Chang, Yves V. Brun, P. Lynne Howell, Lori L. Burrows, Jun Liu   +5 more
doaj   +2 more sources

Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. [PDF]

PLoS ONE, 2011
At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear.
Janice K V Tam, Kwan-Wa Lau, Leo T O Lee, Jessica Y S Chu, Kwong-Man Ng, Alain Fournier, Hubert Vaudry, Billy K C Chow   +7 more
doaj   +1 more source

MOLECULAR EVOLUTION OF GPCRS: Secretin/secretin receptors [PDF]

Journal of Molecular Endocrinology, 2014
In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic secretion. To date, secretin has only been identified in tetrapods, with the earliest diverged secretin found in frogs.
Chow, BKC, JIN, J, Tam, JKV, Lee, LTO
openaire   +4 more sources

Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model

Molecular Metabolism, 2023
Objective: Obesity is a major global health problem which can be targeted with new mechanistic diverse pharmacological interventions. Here we evaluate a new long-acting secretin receptor agonist as a potential treatment for obesity.
Mona Loeffler, Katarina Klepac, Angela Baljuls, Bradford Hamilton, Svenja Mayer-Wrangowski, Peter Haebel, Tina Zimmermann   +6 more
doaj   +1 more source

The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder

Frontiers in Cellular Neuroscience, 2020
Gut peptide hormones are one group of secretory factors produced from gastrointestinal endocrine cells with potent functions in modulating digestive functions.
Xin-Rui Qi, Li Zhang
doaj   +1 more source