Results 11 to 20 of about 34,649 (253)

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor [PDF]

Biochemical Journal, 2017
Previous studies have indicated that the G protein-coupled secretin receptor is present as a homo-dimer, organized through symmetrical contacts in transmembrane domain IV, and that receptor dimerization is critical for high potency signalling by secretin.
Harikumar, Kaleeckal G., Miller, Laurence J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +4 more
core   +3 more sources

Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus

eLife, 2017
Secretins form multimeric channels across the outer membrane of Gram-negative bacteria that mediate the import or export of substrates and/or extrusion of type IV pili.
Edoardo D'Imprima, Ralf Salzer, Ramachandra M Bhaskara, Ricardo Sánchez, Ilona Rose, Lennart Kirchner, Gerhard Hummer, Werner Kühlbrandt, Janet Vonck, Beate Averhoff   +9 more
doaj   +2 more sources

Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and Dynamics

mBio, 2017
The type II secretion system (T2SS) releases large folded exoproteins across the envelope of many Gram-negative pathogens. This secretion process therefore requires specific gating, interacting, and dynamics properties mainly operated by a bipartite ...
Badreddine Douzi, Nhung T. T. Trinh, Sandra Michel-Souzy, Aline Desmyter, Geneviève Ball, Pascale Barbier, Artemis Kosta, Eric Durand, Katrina T. Forest, Christian Cambillau, Alain Roussel, Romé Voulhoux   +11 more
doaj   +2 more sources

Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis. [PDF]

Cell Prolif
Targeting macrophage SCTR mitigates integrated profibrotic, inflammatory, ER stress, and senescent pathways, preserving lung function and revealing a novel therapeutic strategy for silicosis.
Li Y, Li T, Jin F, Liu S, Xu D, Wei Z, Gao X, Cai W, Mao N, Yang F, Zhang H, Shi Y, Xu H.   +12 more
europepmc   +2 more sources

Secretin modulates appetite via brown adipose tissue-brain axis

bioRxiv, 2022
Purpose Secretin activates brown adipose tissue (BAT) and induces satiation in both mice and humans. However, the exact brain mechanism of this satiety inducing, secretin-mediated gut-BAT-brain axis is largely unknown. Methods and results In this placebo-
Lihua Sun, Sanna Laurila, Minna Lahesmaa, E. Rebelos, K. Virtanen, K. Schnabl, M. Klingenspor, L. Nummenmaa, P. Nuutila   +8 more
semanticscholar   +1 more source

Esophageal Perforation in Zollinger-Ellison Syndrome: A Scoping Review of Management and Outcomes. [PDF]

JGH Open
ABSTRACT Esophageal perforation in Zollinger–Ellison syndrome (ZES) is an exceedingly rare and life‐threatening manifestation of gastrinoma‐related acid hypersecretion. While peptic ulceration and severe reflux are recognized complications of ZES, perforation represents the ultimate consequence of uncontrolled hyperacidity. Evidence remains confined to
Fernicola A, Parmeggiani D, Crocetto F, Calogero A, Cece A, Romano D, Benassai G, Quarto G, Santangelo M.   +8 more
europepmc   +2 more sources

Secretin-Enhanced MRCP: How and Why-AJR Expert Panel Narrative Review.

AJR. American journal of roentgenology, 2020
Secretin-enhanced MRCP (S-MRCP) provides multiple advantages compared with standard MRCP for imaging the pancreaticobiliary tree. By using secretin to induce fluid production from the pancreas, and leveraging fluid-sensitive MRCP sequences, S-MRCP ...
J. Swensson, A. Zaheer, D. Conwell, K. Sandrasegaran, R. Manfredi, T. Tirkes   +5 more
semanticscholar   +1 more source

Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor. [PDF]

PLoS ONE, 2016
The pleiotropic role of human secretin (hSCT) validates its potential use as a therapeutic agent. Nevertheless, the structure of secretin in complex with its receptor is necessary to develop a suitable therapeutic agent. Therefore, in an effort to design
Kailash Singh, Vijayalakshmi Senthil, Aloysius Wilfred Raj Arokiaraj, Jérôme Leprince, Benjamin Lefranc, David Vaudry, Ahmed A Allam, Jamaan Ajarem, Billy K C Chow   +8 more
doaj   +1 more source

Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling

Gut Microbes, 2023
Intestinal microbes impact the health of the intestine and organs distal to the gut. Limosilactobacillus reuteri is a human intestinal microbe that promotes normal gut transit, the anti-inflammatory immune system, wound healing, normal social behavior in
Heather A. Danhof, Jihwan Lee, Aanchal Thapa, Robert A. Britton, Sara C. Di Rienzi   +4 more
doaj   +1 more source

Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice

Frontiers in Cellular and Infection Microbiology, 2023
The gut microbiota plays a vital role in maintaining gastrointestinal homeostasis, however, whether it is influenced by gut hormones remains unknown. Secretin is a well-known gastrointestinal hormone produced by enteroendocrine S cells.
Fengwei Zhang, Zhengyi Tao, Congjia Chen, Billy Kwok Chong Chow   +3 more
doaj   +1 more source