Results 11 to 20 of about 28,763 (270)

Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor. [PDF]

PLoS ONE, 2016
The pleiotropic role of human secretin (hSCT) validates its potential use as a therapeutic agent. Nevertheless, the structure of secretin in complex with its receptor is necessary to develop a suitable therapeutic agent. Therefore, in an effort to design
Kailash Singh, Vijayalakshmi Senthil, Aloysius Wilfred Raj Arokiaraj, Jérôme Leprince, Benjamin Lefranc, David Vaudry, Ahmed A Allam, Jamaan Ajarem, Billy K C Chow   +8 more
doaj   +1 more source

Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?

Frontiers in Endocrinology, 2021
Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic
Sanna Laurila, Sanna Laurila, Sanna Laurila, Eleni Rebelos, Miikka-Juhani Honka, Pirjo Nuutila, Pirjo Nuutila   +6 more
doaj   +1 more source

Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling

Gut Microbes, 2023
Intestinal microbes impact the health of the intestine and organs distal to the gut. Limosilactobacillus reuteri is a human intestinal microbe that promotes normal gut transit, the anti-inflammatory immune system, wound healing, normal social behavior in
Heather A. Danhof, Jihwan Lee, Aanchal Thapa, Robert A. Britton, Sara C. Di Rienzi   +4 more
doaj   +1 more source

Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice

Frontiers in Cellular and Infection Microbiology, 2023
The gut microbiota plays a vital role in maintaining gastrointestinal homeostasis, however, whether it is influenced by gut hormones remains unknown. Secretin is a well-known gastrointestinal hormone produced by enteroendocrine S cells.
Fengwei Zhang, Zhengyi Tao, Congjia Chen, Billy Kwok Chong Chow   +3 more
doaj   +1 more source

Esophageal Perforation in Zollinger-Ellison Syndrome: A Scoping Review of Management and Outcomes. [PDF]

JGH Open
ABSTRACT Esophageal perforation in Zollinger–Ellison syndrome (ZES) is an exceedingly rare and life‐threatening manifestation of gastrinoma‐related acid hypersecretion. While peptic ulceration and severe reflux are recognized complications of ZES, perforation represents the ultimate consequence of uncontrolled hyperacidity. Evidence remains confined to
Fernicola A, Parmeggiani D, Crocetto F, Calogero A, Cece A, Romano D, Benassai G, Quarto G, Santangelo M.   +8 more
europepmc   +2 more sources

The Role of Bile in the Regulation of Exocrine Pancreatic Secretion [PDF]

, 1992
As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice.
Adamczyk W, Andrén-Sandberg A, Aronchick CA, Björnsson OG, Björnsson OG, Brand SJ, Burhol PG, Davies HA, Dragstedt LR, Erlinger S, Eyre-Brook IA, Fausa O, Fiedler F, Forell MM, Forell MM, Forell MM, Forell MM, Forell MM, Frühauf S, Fölsch UR, Geratz JD, Gomez G, Green GM, Gries E, Grundy SM, Hanssen LE, Hartmann W, Hellmann G, Holtermuller KH, Holtermuller KH, Hotz J, Ivy AC, Kataoka K, Konturek SJ, Koop I, Koop I, Koop I, Koop I, Koop I, Kurosawa H, Kuroyanagi Y, Lagerlöf HO, Lehnert P, Lueth HC, Malagelada J-R, Malagelada J-R, Malagelada J-R, Mellanby J, Meyer JH, Miyasaka K, Miyasaka K, Miyasaka K, Miyasaka K, Nakamura R, Nakamura R, Namba M, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, Osnes M, Otte M, Peter Lehnert, Riepl RL, Riepl RL, Riepl RL, Riepl RL, Rudolf L. Riepl, Schaffalitzky de Muckadell OB, Shiratori K, Smallwood RA, Staub VL, Thomas JE, van Levan H, Wormsley KG   +75 more
core   +1 more source

Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat.

PLoS ONE, 2011
Background & aimsSecretin induces bicarbonate-rich hydrocholeresis in healthy individuals, but not in untreated patients with primary biliary cirrhosis (PBC). Ursodeoxycholic acid (UDCA)--the first choice treatment for PBC--restores the secretin response.
Miriam Úriz, Elena Sáez, Jesús Prieto, Juan F Medina, Jesús M Banales   +4 more
doaj   +1 more source

Efficacy and Safety of Pancreatic Juice Cytology with Synthetic Secretin in Diagnosing Malignant Intraductal Papillary Mucinous Neoplasms of the Pancreas

Diagnostics, 2022
The risk of malignant transformation of intraductal papillary mucinous neoplasm (IPMN) is presently assessed using imaging, which remains unsatisfactory.
Yohei Takeda, Kazuya Matsumoto, Takumi Onoyama, Taro Yamashita, Hiroki Koda, Wataru Hamamoto, Yuri Sakamoto, Takuya Shimosaka, Shiho Kawahara, Yasushi Horie, Hajime Isomoto   +10 more
doaj   +1 more source

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor [PDF]

, 2017
Previous studies have indicated that the G protein-coupled secretin receptor is present as a homo-dimer, organized through symmetrical contacts in transmembrane domain IV, and that receptor dimerization is critical for high potency signalling by secretin.
Harikumar, Kaleeckal G., Miller, Laurence J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +4 more
core   +2 more sources

Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice

Frontiers in Cellular Neuroscience, 2019
In mammals, reproduction is regulated by a wide range of metabolic hormones that maintain the proper energy balance. In addition to regulating feeding and energy expenditure, these metabolic messengers also modulate the functional performance of the ...
Veronika Csillag, Veronika Csillag, Csaba Vastagh, Zsolt Liposits, Zsolt Liposits, Imre Farkas   +5 more
doaj   +1 more source