Results 91 to 100 of about 166,195 (340)

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]

, 2017
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR, Douglass S, Kalas W, Mathiak M, Onita T, Zhu YH   +5 more
core   +2 more sources

Tissue specific induction of p62/sqstm1 by farnesoid X receptor [PDF]

, 2012
Background: Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis. FXR is protective against carcinogenesis and inflammation in
Ann M. Thomas, Bo Kong, Grace L. Guo, Guodong Li, Jean-Marc A. Lobaccaro, Jessica A. Williams, Le Zhan, Wen Xie, Wen-Xing Ding, Yuka Inaba   +9 more
core   +7 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Zymophagy: Selective Autophagy of Secretory Granules [PDF]

International Journal of Cell Biology, 2012
Timing is everything. That's especially true when it comes to the activation of enzymes created by the pancreas to break down food. Pancreatic enzymes are packed in secretory granules as precursor molecules called zymogens. In physiological conditions, those zymogens are activated only when they reach the gut, where they get to work releasing and ...
openaire   +4 more sources

Selective Autophagy: Talking with the UPS [PDF]

Cell Biochemistry and Biophysics, 2013
Far from now are the days when investigators raced to identify the proteolytic system responsible for the degradation of their favorite protein. Nowadays, it is well accepted that a given protein can be degraded by different systems depending on factors such as cell type, cellular conditions, or functionality of each proteolytic pathway.
Caroline, Park, Ana Maria, Cuervo
openaire   +2 more sources

The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]

, 2020
Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core   +1 more source

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation [PDF]

, 2015
Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under
Belkin, Brady, Cantley, Caputo, Carnero, Cornwall, Cuervo, Cuervo, De Strooper, Debnath, Denk, Deutsch, Dikic, Djavaheri-Mergny, Eckert, Esposito, Facchiano, Fesus, Graham, Griffin, Griffin, Ha, Han, Johansen, Johansen, Ju, Khosla, Khosla, Komatsu, Kumar, Ledesma, Lenz, Levine, Levine, Liao, Liu, Lopez-Berestein, Mazurek, Mehta, Murphy, Ortona, Ozpolat, Palmieri, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Rao, Rice, Rodolfo, Saito, Semenza, Semenza, Tavernarakis, Wang, Wang, White   +61 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Physiological Stress Response by Selective Autophagy

Journal of Molecular Biology, 2020
Cells are constantly challenged by endogenous and exogenous stress sources. To cope with them, organisms have developed a series of defensive mechanisms to prevent and intercept the threats and to repair the generated damage. Autophagy, once defined as a waste-disposal or non-specific degradative pathway, has arisen as a new organizer of the different ...
Pablo, Sánchez-Martín, Masaaki, Komatsu   +1 more
openaire   +2 more sources