Results 201 to 210 of about 166,195 (340)

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Peiminine-Induced Selective Autophagy of AIM2 Inflammasomes Rescues Cerebral Ischemic Injury. [PDF]

J Am Heart Assoc
Zhou ZC, Liu MT, Fangma YJ, Wan BJ, Zhou J, Zhang XL, Yan YT, Deng SH, Zhang Y, Zhang YJ, Li WL, Chen Z, Zheng YR.   +12 more
europepmc   +1 more source

An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy

, 2016
Lei Sun, Wu-Yan Xia, Shaohua Zhao, Ning Liu, Shanshan Liu, Peng Xiu, Linfeng Li, Xuelei Cao, Jianxin Gao   +8 more
openalex   +2 more sources

Selective autophagy against membranous compartments [PDF]

, 2014
Felipe X. Pimentel‐Muiños, Emilio Boada-Romero   +1 more
openalex   +1 more source

Orchestration of selective autophagy by cargo receptors

, 2022
Elias Adriaenssens, Luca Ferrari, Sascha Martens   +2 more
openalex   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Sir2 regulates selective autophagy in stationary-phase yeast cells. [PDF]

Microb Cell
Ryu JI, Jung J, Kim JY.
europepmc   +1 more source

EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway

Ho Woon Lee, Jee‐Hye Choi, Dongbeom Seo, Gavaachimed Lkhagvasuren, Jaesung Choi, Sehwan Park, Na Young Min, Dong Ho Lee, Hyoweon Bang, Seung Wook Ham, Jung-Woong Kim, Sung Chul Lee, Sangmyung Rhee, Sang‐Beom Seo, Kwang-Ho Lee   +14 more
openalex   +1 more source