Results 211 to 220 of about 166,195 (340)

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Emerging perspectives on the selective autophagy of melanosomes: melanophagy. [PDF]

Exp Mol Med
Park NY, Kim SH, Jo DS, Cho DH.
europepmc   +1 more source

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform [PDF]

, 2020
Maria Zachari, Sigurður Guðmundsson, Ziyue Li, Maria Manifava, Fiorella Cugliandolo, Ronak Shah, Matthew D. Smith, James Stronge, Eleftherios Karanasios, Caterina Piunti, Chieko Kishi‐Itakura, Helena Vihinen, Eija Jokitalo, Jun‐Lin Guan, Folma Buß, Andrew Smith, Simon Walker, Eeva‐Liisa Eskelinen, Nicholas T. Ktistakis   +18 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

SELECTIVE AUTOPHAGY: CAN WE TARGET IT TO EXTEND HEALTH-SPAN? [PDF]

, 2018
Ana María Cuervo
openalex   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Post-translational modifications of selective autophagy receptors: orchestrating cellular homeostasis, disease pathogenesis, and therapeutic opportunities. [PDF]

Cell Mol Biol Lett
Zhu W, Wang X, Li Q, Jiang X, Xu G.
europepmc   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

V-ATPase-dependent induction of selective autophagy. [PDF]

Nat Commun
Huang Y, Dialynaki D, Lei Y, Zhang Z, Evans CR, Klionsky DJ.   +5 more
europepmc   +1 more source

Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer’s disease

, 2021
Arubala P. Reddy, Neha Sawant, Hallie Morton, Sudhir Kshirsagar, Lloyd E. Bunquin, Xiangling Yin, P. Hemachandra Reddy   +6 more
openalex   +2 more sources