Results 71 to 80 of about 20,702 (201)

Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology - a subgroup analysis of a multicenter, phase III trial [PDF]

, 2013
Background: In a previous analysis (Int J Radiat Oncol Biol Phys 70:828-835,2010), we assessed whether an adjuvant supplementation with selenium (Se) improves Se status and reduces the radiation-induced side-effects of patients treated by adjuvant ...
Adamietz, Irenäus A., Baaske, Dieter, Berndt-Skorka, Regina, Buentzel, Jens, Eich, Hans-Theodor, Glatzel, Michael, Huebner, Jutta, Kisters, Klaus, Kundt, Guenther, Micke, Oliver, Muecke, Ralph, Prott, Franz-Josef, Reichl, Berthold, Schaefer, Ulrich, Schomburg, Lutz   +14 more
core   +1 more source

Efficiency of Mammalian Selenocysteine Incorporation [PDF]

Journal of Biological Chemistry, 2004
Five components have thus far been identified that are necessary for the incorporation of selenocysteine (Sec) into approximately 25 mammalian proteins. Two of these are cis sequences, a SECIS element in the 3'-untranslated region and a Sec codon (UGA) in the coding region.
Anupama, Mehta, Cheryl M, Rebsch, Scott A, Kinzy, Julia E, Fletcher, Paul R, Copeland   +4 more
openaire   +2 more sources

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Folding of peptides and proteins: role of disulfide bonds, recent developments

Biomolecular Concepts, 2013
Disulfide-containing proteins are ideal models for studies of protein folding as the folding intermediates can be observed, trapped, and separated by HPLC during the folding reaction.
Hidaka Yuji, Shimamoto Shigeru
doaj   +1 more source

Gold amides as anticancer drugs: synthesis and activity studies [PDF]

, 2013
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery.
Amagai, Amruta Shrikhande, Bjornstedt, Chen, Chris Gallop, Cox, Davis, Eddy M. E. Viseux, Eva Hoffmann, Fricker, Gabbiani, Helen Yong, Hickey, Hill, Lemke, Lima, Mariusz Bobin, Mark Roe, Mezailles, Modica-Napolitano, Omata, Orvig, Ott, Patra, Poole, Rebecca Gates, Shuvashri Chaudhuri, Sonya Newcombe, Stallings-Mann, Thaqi, Wetzel, Yan, Yannick Pace, Zhang, Zhang   +34 more
core   +1 more source

Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging

VIEW, EarlyView.
Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao, Jingyu Deng, Qin Li, Tong Xia, Xun Yang, Simei Yang, Changzhen Sun, Xia Xiong, Li Liu   +8 more
wiley   +1 more source

An atlas of plant selenium metabolism

New Phytologist, EarlyView.
Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude, Mark G. M. Aarts, Michela Schiavon, Antony van der Ent   +3 more
wiley   +1 more source

Species-Specific, pH-Independent, Standard Redox Potential of Selenocysteine and Selenocysteamine

Antioxidants, 2020
Microscopic redox equilibrium constants and standard redox potential values were determined to quantify selenolate-diselenide equilibria of biological significance.
Tamás Pálla, Arash Mirzahosseini, Béla Noszál   +2 more
doaj   +1 more source

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

EMBO Molecular Medicine, 2023
Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR‐activation screens in ferroptosis
Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti‐Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli   +32 more
doaj   +1 more source

Facile Recoding of Selenocysteine in Nature [PDF]

Angewandte Chemie International Edition, 2016
AbstractSelenocysteine (Sec or U) is encoded by UGA, a stop codon reassigned by a Sec‐specific elongation factor and a distinctive RNA structure. To discover possible code variations in extant organisms we analyzed 6.4 trillion base pairs of metagenomic sequences and 24 903 microbial genomes for tRNASec species.
Mukai, Takahito, Englert, Markus, Tripp, H James, Miller, Corwin, Ivanova, Natalia N, Rubin, Edward M, Kyrpides, Nikos C, Söll, Dieter   +7 more
openaire   +5 more sources