Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases. [PDF]
PLoS Computational BiologyGenome annotations provide the essential framework for genomic analyses, capturing our current knowledge of gene structure and function as inferred from computational predictions and experimental evidence.
Max Ticó +3 more
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Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα. [PDF]
PLoS ONE, 2013 Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another.
Mohamed E Moustafa +13 more
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deep-Sep: a deep learning-based method for fast and accurate prediction of selenoprotein genes in bacteria [PDF]
mSystemsSelenoproteins are a special group of proteins with major roles in cellular antioxidant defense. They contain the 21st amino acid selenocysteine (Sec) in the active sites, which is encoded by an in-frame UGA codon.
Yao Xiao, Yan Zhang
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Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study [PDF]
Scientific ReportsEssential trace elements, such as iron (Fe) and selenium (Se), play physiological roles in our body, whereas environmental toxic metals, such as arsenic (As), cadmium (Cd), and mercury (Hg), are known to be associated with various disease risks. However,
Yoshiro Saito +11 more
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Novel selenoprotein neighborhoods suggest specialized biochemical processes [PDF]
mSystemsProkaryotic genomes encode selenoproteins sparsely, roughly one protein per 5,000. Finding novel selenoprotein families can expose unknown biological processes that are enabled, or at least enhanced, by having a selenium atom replace a sulfur atom in ...
Daniel H. Haft, Igor Tolstoy
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eIF3 Interacts with Selenoprotein mRNAs
Biomolecules, 2022 The synthesis of selenoproteins requires the co-translational recoding of an in-frame UGASec codon. Interactions between the Selenocysteine Insertion Sequence (SECIS) and the SECIS binding protein 2 (SBP2) in the 3′untranslated region (3′UTR) of ...
Hassan Hayek +2 more
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Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans
Frontiers in Nutrition, 2021 Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe +13 more
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Redox Biology, 2023 TXNL1 (also named TRP32, for thioredoxin related protein of 32 kDa) is a cytosolic thioredoxin-fold protein expressed in all cell types and conserved from yeast to mammals, but with yet poorly known function.
Attila Andor +6 more
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A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin [PDF]
, 2012 Background: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect
Eliseo Guallar +6 more
core +12 more sources
Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap). [PDF]
PLoS ONE, 2015 Selenocysteine tRNA 1 associated protein (Trnau1ap) has been characterized as a tRNA[Ser]Sec-binding protein of 43 kDa, hence initially named SECp43. Previous studies reported its presence in complexes containing tRNA[Ser]Sec implying a role of SECp43 as
Yassin Mahdi +9 more
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