A Pan-Cancer Analysis of the Role of Selenoprotein P mRNA in Tumorigenesis [PDF]
International Journal of General Medicine, 2021 Yanni Yang,1– 3,* Daning Li,1,* Wentao Wu,1 Dingxing Huang,1 Haishi Zheng,3 Yirixiati Aihaiti3 1School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China; 2Shaanxi University of ...
Yang Y +5 more
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Circulating selenoprotein P levels predict glucose‐lowering and insulinotropic effects of metformin, but not alogliptin: A post‐hoc analysis [PDF]
Journal of Diabetes Investigation, 2023 Aims/Introduction Selenoprotein P (SeP; encoded by SEPP1 in humans) is a hepatokine that causes impaired insulin secretion and insulin resistance. Metformin downregulates SELENOP promoter activity through an adenosine monophosphate‐activated kinase ...
Yumie Takeshita +7 more
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A County-Level Spatial Study of Serum Selenoprotein P and Keshan Disease [PDF]
Frontiers in Nutrition, 2022 BackgroundKeshan disease (KD) is strongly associated with selenium deficiency. Selenoprotein P (SELENOP) is a recognized molecular biomarker of selenoproteins and an important indicator of selenium nutrition.
Yuehui Jia +16 more
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Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients.
PLoS ONE, 2012 Selenium (Se) is an essential trace element for selenoprotein biosynthesis. Selenoproteins have been implicated in cancer risk and tumor development. Selenoprotein P (SePP) serves as the major Se transport protein in blood and as reliable biomarker of Se
Hellmuth A Meyer +7 more
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NRF2-dependent suppression of selenoprotein P expression promotes intracellular selenium metabolic remodeling and upregulation of antioxidant selenoproteins in hepatocellular carcinoma. [PDF]
Redox BiolArisawa K +7 more
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Ethanol enhances selenoprotein P expression via ERK-FoxO3a axis in HepG2 cells. [PDF]
J Clin Biochem NutrChen J, Mita Y, Noguchi N.
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The selenoprotein P–LRP5/6–WNT3A complex promotes tumorigenesis in sporadic colorectal cancer [PDF]
J Clin Invest, 2023 K. Sandeep Prabhu
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Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans
Frontiers in Nutrition, 2021 Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe +13 more
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The selenium content of SEPP1 versus selenium requirements in vertebrates [PDF]
PeerJ, 2015 Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. For vertebrates, the Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we
Sam Penglase +2 more
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