The role of selenium in the pathogenesis of thyroid disease
Клиническая и экспериментальная тиреоидология, 2019 The past few years have been actively discussing the role of individual macro- and micronutrients as factors regulating the functional activity of organs and systems and reducing the risk of developing a number of diseases, including thyroid diseases.
Ekaterina A. Troshina +2 more
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Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]
, 2011 The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
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Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors [PDF]
, 2009 International audienceBACKGROUND: In humans, mutations in the SEPN1 gene, encoding selenoprotein N (SelN), are involved in early onset recessive neuromuscular disorders, referred to as SEPN1-related-myopathies. The mechanisms behind these pathologies are
Alain Krol +8 more
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Bioinformatic analysis of glutathione peroxidase family from theobroma cacao and gene expression during Moniliophthora perniciosa infection.[Poster-B185] [PDF]
, 2018 Glutathione peroxidases (GPXs) are enzymes which are part of the antioxidant system of the cell. Mammalian GPXs are known as selenoproteins because containing the selenocysteine (Sec) amino acid. In plants, these proteins are less known.
Andrade, Bruno Silva +4 more
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Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P [PDF]
, 2017 Selenoprotein P (SELENOP) is a liver-derived transporter of selenium (Se) in blood, and a meaningful biomarker of Se status. Se is an essential trace element for the biosynthesis of enzymatically-active selenoproteins, protecting the organism from ...
Hybsier, Sandra +10 more
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Selenoproteins and selenoproteomes
, 2007 Recent progress in high-throughput sequencing and analysis allowed efficient identification of selenocysteine-containing proteins in sequence databases, including full sets of selenoproteins in organisms, designated selenoproteomes. Information is currently available on selenoproteomes from all major model organisms as well as humans, which have 25 ...
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Characterization of Fungal Communities Associated with Aquilaria spp. for the Production of Agarwood. [Poster-B123] [PDF]
, 2018 Aquilaria is a tree genus distributed in Southeast Asia, known for its oleoresin production. The induction of this oleoresin is described as a stress reaction by injury and, or fungal infection. In response to this stress, Aquilaria spp.
Amusant, Nadine +7 more
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Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]
, 2015 The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M +12 more
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Selenium: Chemical biology, toxicology and radioprotection
Biomedical Research Journal, 2016 Selenium, a micronutrient and an active constituent of important redox enzymes like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), has been investigated extensively by researchers all over the world for the last four to five decades. Both
Kavirayani Indira Priyadarsini +2 more
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Selenoproteins and Thyroid Cancer
, 2011 Selenoproteins, in which Se exists in the form of selenocysteine, are essential for protection against oxidative damage and cancer. Genetic data has provided evidence that reduced levels of these proteins, induced by loss of heterozygosity or chromosomal alterations [1], result in cellular oxidative stress as well as derangement of signaling cascades ...
Duntas, L.H., Smyth, P.P.A.
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