Results 1 to 10 of about 14,594 (219)

Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application

Biosensors, 2022
Small-molecule contaminants, such as antibiotics, pesticides, and plasticizers, have emerged as one of the substances most detrimental to human health and the environment.
Sin Yu Lam, Hill Lam Lau, Chun Kit Kwok
doaj   +2 more sources

Advantages, applications, and future directions of in vivo aptamer SELEX: A review

Molecular Therapy: Nucleic Acids
In vivo systematic evolution of ligands by exponential enrichment (SELEX) emerged as a transformative technique for directly identifying aptamers within living organisms.
Minchuan Lyu, Chi Ho Chan, Ziqi Chen, Yumeng Liu, Yuanyuan Yu   +4 more
doaj   +2 more sources

Advances in Aptamer-Based Biosensors and Cell-Internalizing SELEX Technology for Diagnostic and Therapeutic Application

Biosensors, 2022
Aptamers are a group of synthetic single-stranded nucleic acids. They are generated from a random library of single-stranded DNA or RNA by a technology named systematic evolution of ligands by exponential enrichment (SELEX). SELEX is a repetitive process
Zixuen Gan, Muhamad Aidilfitri Mohamad Roslan, Mohd Yunus Abd Shukor, Murni Halim, Nur Adeela Yasid, Jaafar Abdullah, Ina Salwany Md Yasin, Helmi Wasoh   +7 more
doaj   +2 more sources

Advancements in SELEX Technology for Aptamers and Emerging Applications in Therapeutics and Drug Delivery

Biomolecules
Nucleic acid aptamers, selected through the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are short nucleic acid sequences that exhibit high affinity and specificity towards diverse targets.
Liangjie Feng, Yu Sun, Wenshen Jia, Yang Yu, Chang Liu, Jing Yang, Yunxia Luan, Jin Chen, Fengchao Wang   +8 more
doaj   +2 more sources

Aptamer Screening: Current Methods and Future Trend towards Non-SELEX Approach

Biosensors
Aptamers are nucleic acid sequences that specifically bind with target molecules and are vital to applications such as biosensing, drug development, disease diagnostics, etc.
Zhihui Fang, Xiaorui Feng, Fan Tang, Han Jiang, Shuyuan Han, Ran Tao, Chenze Lu   +6 more
doaj   +2 more sources

Inside the Black Box: What Makes SELEX Better?

Molecules, 2019
Aptamers are small oligonucleotides that are capable of binding specifically to a target, with impressive potential for analysis, diagnostics, and therapeutics applications.
Natalia Komarova, Alexander Kuznetsov
doaj   +2 more sources

Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine

International Journal of Molecular Sciences, 2017
Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process of selecting an aptamer is called Systematic Evolution of Ligands by Exponential Enrichment (SELEX).
Zhen-Jian Zhuo, Yuanyuan Yu, Jie Li
exaly   +2 more sources

High-throughput sequencing SELEX for the determination of DNA-binding protein specificities in vitro

STAR Protocols, 2022
Summary: High-throughput sequencing SELEX (HT-SELEX) is a powerful technique for unbiased determination of preferred target motifs of DNA-binding proteins in vitro.
Raphaël Pantier, Kashyap Chhatbar, Grace Alston, Heng Yang Lee, Adrian Bird   +4 more
doaj   +2 more sources

Recent Advances in the Optimization of Nucleic Acid Aptamers and Aptasensors [PDF]

Biosensors
Nucleic acid aptamers are single-stranded DNA or RNA molecules that can bind to a target with high specificity and affinity, as screened by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX).
Yuan Wang, Mengyan Nie
doaj   +2 more sources

Development of RNA G-quadruplex (rG4)-targeting l-RNA aptamers by rG4-SELEX

Nature Protocols, 2022
Mubarak I. Umar, Chun-Yin Chan, Chun Kit Kwok   +2 more
exaly   +2 more sources