Results 21 to 30 of about 14,594 (219)
Aptamers in Therapeutics [PDF]
Journal of Clinical and Diagnostic Research, 2016 Aptamers are single strand DNA or RNA molecules, selected by an iterative process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX).
Abhishek Parashar
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Synthetic biology tools to promote the folding and function of RNA aptamers in mammalian cells
RNA Biology, 2023 RNA aptamers are structured RNAs that can bind to diverse ligands, including proteins, metabolites, and other small molecules. RNA aptamers are widely used as in vitro affinity reagents.
Qian Hou, Samie R. Jaffrey
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Libraries for genomic SELEX [PDF]
Nucleic Acids Research, 1997 An increasing number of proteins are being identified that regulate gene expression by binding specific nucleic acidsin vivo. A method termed genomic SELEX facilitates the rapid identification of networks of protein-nucleic acid interactions by identifying within the genomic sequences of an organism the highest affinity sites for any protein of the ...
B S, Singer +3 more
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AIP Conference Proceedings, 2000 Talk given at the Session honoring Leon Lederman at the VII Mexican Workshop on Particles and Fields, Merida, Mexico, November 10-17, 1999.
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SELEX: Critical factors and optimization strategies for successful aptamer selection
Biotechnology and applied biochemistry, 2021 Within the last decade, the application range of aptamers in biochemistry and medicine has expanded rapidly. More than just a replacement for antibodies, these intrinsically structured RNA‐ or DNA‐oligonucleotides show great potential for utilization in ...
Michael Kohlberger, G. Gadermaier
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The application of Aptamer in biomarker discovery
Biomarker Research, 2023 Biomarkers are detectable molecules that can reflect specific physiological states of cells, organs, and organisms and therefore be regarded as indicators for specific diseases. And the discovery of biomarkers plays an essential role in cancer management
Yongshu Li +11 more
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An improved SELEX-Seq strategy for characterizing DNA-binding specificity of transcription factor: NF-κB as an example. [PDF]
PLoS ONE, 2013 SELEX-Seq is now the optimal high-throughput technique for characterizing DNA-binding specificities of transcription factors. In this study, we introduced an improved EMSA-based SELEX-Seq strategy with several advantages.
Guangming Gu +4 more
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Aptamers for mycotoxin recognition in food: Recent advances and future considerations
Advanced Agrochem, 2023 The contamination of mycotoxin in food has posed a serious threat to human health and safety. Accurate detection of mycotoxins provides a strong guarantee for food safety.
Peng Fang, Hao Qu, Yu Mao, Lei Zheng
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Selection of allosteric dnazymes that can sense phenylalanine by expression-SELEX
Nucleic Acids Research, 2023 Aptamers are ligand-binding RNA or DNA molecules and have been widely examined as biosensors, diagnostic tools, and therapeutic agents. The application of aptamers as biosensors commonly requires an expression platform to produce a signal to report the ...
Binfen Chen +5 more
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BioResearch Open Access, 2012 Aptamers are molecules identified from large combinatorial nucleic acid libraries by their high affinity to target molecules. Due to a variety of desired properties, aptamers are attractive alternatives to antibodies in molecular biology and medical applications.
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