Results 21 to 30 of about 22,058 (247)

Aptamers in Therapeutics [PDF]

Journal of Clinical and Diagnostic Research, 2016
Aptamers are single strand DNA or RNA molecules, selected by an iterative process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX).
Abhishek Parashar
doaj   +1 more source

Synthetic biology tools to promote the folding and function of RNA aptamers in mammalian cells

RNA Biology, 2023
RNA aptamers are structured RNAs that can bind to diverse ligands, including proteins, metabolites, and other small molecules. RNA aptamers are widely used as in vitro affinity reagents.
Qian Hou, Samie R. Jaffrey
doaj   +1 more source

Libraries for genomic SELEX [PDF]

Nucleic Acids Research, 1997
An increasing number of proteins are being identified that regulate gene expression by binding specific nucleic acidsin vivo. A method termed genomic SELEX facilitates the rapid identification of networks of protein-nucleic acid interactions by identifying within the genomic sequences of an organism the highest affinity sites for any protein of the ...
B S, Singer, T, Shtatland, D, Brown, L, Gold   +3 more
openaire   +2 more sources

Plate cell – SELEX v1 [PDF]

, 2019
Aptamers are short single-stranded oligonucleotide (DNA or RNA) molecules with the ability to bind to other molecules with high affinity and specificity. Nowadays, aptamers are used as biosensing molecules with broader applications, such as ribozymes (RNA enzyme molecules with catalytic activities); riboswitches (modulating translational activities ...
Laura Armero, Claudia Troncone Clemente
openalex   +2 more sources

An improved SELEX-Seq strategy for characterizing DNA-binding specificity of transcription factor: NF-κB as an example. [PDF]

PLoS ONE, 2013
SELEX-Seq is now the optimal high-throughput technique for characterizing DNA-binding specificities of transcription factors. In this study, we introduced an improved EMSA-based SELEX-Seq strategy with several advantages.
Guangming Gu, Tingting Wang, Yang Yang, Xinhui Xu, Jinke Wang   +4 more
doaj   +1 more source

Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application

Biosensors, 2022
Small-molecule contaminants, such as antibiotics, pesticides, and plasticizers, have emerged as one of the substances most detrimental to human health and the environment.
Sin Yu Lam, Hill Lam Lau, Chun Kit Kwok
doaj   +1 more source

The application of Aptamer in biomarker discovery

Biomarker Research, 2023
Biomarkers are detectable molecules that can reflect specific physiological states of cells, organs, and organisms and therefore be regarded as indicators for specific diseases. And the discovery of biomarkers plays an essential role in cancer management
Yongshu Li, Winnie Wailing TAM, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu, Yunhua Gao   +11 more
doaj   +1 more source

Aptamers for mycotoxin recognition in food: Recent advances and future considerations

Advanced Agrochem, 2023
The contamination of mycotoxin in food has posed a serious threat to human health and safety. Accurate detection of mycotoxins provides a strong guarantee for food safety.
Peng Fang, Hao Qu, Yu Mao, Lei Zheng
doaj   +1 more source

First Measurement of pi e -> pi e gamma Pion Virtual Compton Scattering [PDF]

, 2002
Pion Virtual Compton Scattering (VCS) via the reaction pi e --> pi e gamma was observed in the Fermilab E781 SELEX experiment. SELEX used a 600 GeV/c pi- beam incident on target atomic electrons, detecting the incident pi- and the final state pi ...
A. A. Vorobyov, A. G. Atamantchouk, A. G. Dolgolenko, A. G. Krivshich, A. I. Kulyavtsev, A. I. Sitnikov, A. Klein, A. Kushnirenko, A. Lamberto, A. M. F. Endler, A. Morelos, A. N. Vasiliev, A. Ocherashvili, A. Ocherashvili, A. P. Kozhevnikov, A. P. Nilov, A. Penzo, A. V. Evdokimov, A. V. Nemitkin, A.I. L’vov, A.M. Baldin, B. Pasquini, B. Pouh, B. V. Razmyslovich, B.R. Holstein, C. Caso, C. Newsom, C. O. Escobar, C. Unkmeir, C. Unkmeir, D. Babusci, D. Mao, D. Morgan, D. Skow, D. V. Vavilov, E. Gülmez, E. M. Leikin, E. McCliment, E. Ozel, E. Ramberg, F. G. Garcia, G. Alkhazov, G. B. Dzyubenko, G. F. Rappazzo, G. P. Thomas, G. V. Davidenko, G.P. Lepage, H. Krüger, He Kangling, I. Eschrich, I. Eschrich, I. Giller, I. Konorov, I. Larin, I. S. Filimonov, J. Boyer, J. Engelfried, J. Kilmer, J. Lach, J. Roche, J. Russ, J. Simon, J. You, K. D. Nelson, K. Vorwalter, L. Emediato, L. G. Landsberg, L. J. Dauwe, L. M. Kochenda, L. N. Uvarov, L. Stutte, Li Yunshan, M. A. Kubantsev, M. A. Moinester, M. Gaspero, M. Iori, M. Kaya, M. Luksys, M. Mattson, M. Procario, M. Srivastava, M. Svoiski, M. Y. Balatz, Mao Chensheng, Mao Zhenlin, N. F. Bondar, N. K. Terentyev, N. P. Kuropatkin, P. Gouffon, P. Mathew, P. Pogodin, P. S. Cooper, P. Schiavon, P. V. Neoustroev, R. Edelstein, R. Zukanovich-Funchal, S. B. Nurushev, S. I. Petrenko, S. Kerhoas, S. Kwan, S. Ozkorucuklu, S. Scherer, S. Scherer, S. Y. Jun, T. Lungov, T.A. Aibergenov, U. Dersch, V. A. Prutskoi, V. A. Victorov, V. E. Vishnyakov, V. F. Kurshetsov, V. I. Rud, V. J. Smith, V. L. Golovtsov, V. Matveev, V. P. Kubarovsky, V. P. Maleev, V. S. Verebryusov, V. Steiner, V. Stepanov, V. T. Kim, V. V. Molchanov, V.A. Petrun’kin, Y. Onel, Yu.M. Antipov, Yu.M. Antipov, Zhao Wenheng, Zheng Shuchen   +127 more
core   +2 more sources

Cell-SELEX Technology [PDF]

BioResearch Open Access, 2012
Aptamers are molecules identified from large combinatorial nucleic acid libraries by their high affinity to target molecules. Due to a variety of desired properties, aptamers are attractive alternatives to antibodies in molecular biology and medical applications.
openaire   +2 more sources