Results 61 to 70 of about 14,594 (219)

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Aptamer-based Theranostics in Oncology: Design Strategies and Limitations

BIO Integration
Cancer remains a major global health burden, necessitating innovative approaches for improved diagnosis and treatment. Aptamer-based theranostics have gained attention in the field of cancer research and treatment.
Jyoti Trivedi, Mohammad Yasir, Rahul K. Maurya, Alok Shiomurti Tripathi   +3 more
doaj   +1 more source

Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX

Molecular Therapy: Nucleic Acids, 2019
We present a rapidly neutralizable and highly anticoagulant thrombin-binding aptamer with a short toehold sequence, originally discovered by systematic evolution of ligands by exponential enrichment (SELEX) with microbead-assisted capillary ...
Koji Wakui, Toru Yoshitomi, Akane Yamaguchi, Maho Tsuchida, Shingo Saito, Masami Shibukawa, Hitoshi Furusho, Keitaro Yoshimoto   +7 more
doaj   +1 more source

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

New Configurations of Low-Cost Dual-Polarized Printed Antennas for UWB Arrays

International Journal of Antennas and Propagation, 2012
A novel class of structures is proposed to realize ultra-wide-band radiating elements for large arrays, providing dual polarization, beam scanning, and compact and inexpensive realization based on suitable rhombic arrangements of dipoles printed on low ...
Guido Valerio, Simona Mazzocchi, Alessandro Galli, Matteo Ciattaglia, Marco Zucca   +4 more
doaj   +1 more source

CRISPR Assays for Protein Detection

Chemistry–Methods, Volume 6, Issue 3, March 2026.
This review summarizes recent advances in CRISPR–Cas–based strategies for protein detection. Particular focus is placed on recognition element–based approaches, in which antibodies, aptamers, or DNAzymes convert protein binding into CRISPR‐readable nucleic acid signals, and activity‐based strategies that exploit intrinsic protein functions to trigger ...
Luca Capelli, Elena Spezzani, Dharshini Raghavan, Chiara Micucci, Alessandra Zanut, Alessandro Bertucci   +5 more
wiley   +1 more source

Aptamer‐Based Approaches for Influenza Virus Detection: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Influenza remains a globally prevalent respiratory infection that is challenging to diagnose accurately. This systematic review focuses on aptamer‐based tools for influenza virus detection, aiming to overcome the limitations of traditional diagnostic methods.
Javad Charostad, Zohreh‐al‐sadat Ghoreshi, Nasir Arefinia, Faranak Salajegheh, Niloofar Farsiu, Mohammad Rezaei Zadeh Rukerd, Mohsen Nakhaie   +6 more
wiley   +1 more source

Capture-SELEX: Selection of DNA Aptamers for Aminoglycoside Antibiotics

Journal of Analytical Methods in Chemistry, 2012
Small organic molecules are challenging targets for an aptamer selection using the SELEX technology (SELEX—Systematic Evolution of Ligans by EXponential enrichment).
Regina Stoltenburg, Nadia Nikolaus, Beate Strehlitz   +2 more
doaj   +1 more source

A Highlight of Recent Advances in Aptamer Technology and Its Application

Molecules, 2015
Aptamers and SELEX (systematic evolution of ligands by exponential enrichment) technology have gained increasing attention over the past 25 years. Despite their functional similarity to protein antibodies, oligonucleotide aptamers have many unique ...
Hongguang Sun, Youli Zu
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source