Results 71 to 80 of about 14,594 (219)
IMPATIENT-qPCR: monitoring SELEX success during in vitro aptamer evolution
Applied Microbiology and BiotechnologySELEX (Systematic Evolution of Ligands by Exponential enrichment) processes aim on the evolution of high-affinity aptamers as binding entities in diagnostics and biosensing.
Ann-Kathrin Kissmann +9 more
semanticscholar +1 more source
Hyperon physics results from SELEX [PDF]
AIP Conference Proceedings, 1999 13 pages, 5 eps figures, LaTeX, uses aipproc.cls.
openaire +2 more sources
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity
Advanced Materials, Volume 38, Issue 12, 25 February 2026.Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song +9 more
wiley +1 more source
Microtitre Plate Based Cell-SELEX Method
Bio-Protocol, 2018 Aptamers have emerged as a novel category in the field of bioreceptors due to their wide applications ranging from biosensing to therapeutics. Several variations of their screening process, called SELEX have been reported which can yield sequences with ...
Munish Shorie, Harmanjit Kaur
doaj +1 more source
Accelerating Post-SELEX Aptamer Engineering Using Exonuclease Digestion.
Journal of the American Chemical Society, 2020 The systematic evolution of ligands by exponential enrichment (SELEX) process enables the isolation of aptamers from random oligonucleotide libraries. However, it is generally difficult to identify the best aptamer from the resulting sequences, and the ...
Juan Canoura +5 more
semanticscholar +1 more source
Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge?
Molecular Therapy: Nucleic Acids, 2020 Targeted therapeutics underwent a revolution with the entry of monoclonal antibodies in the medical toolkit. Oligonucleotide aptamers form another family of target agents that have been lagging behind in reaching the clinical arena in spite of their ...
Mayte Sola +6 more
semanticscholar +1 more source
RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma
Molecular Therapy: Nucleic Acids, 2019 Nucleic acid aptamers are often referred to as chemical antibodies. Because they possess several advantages, like their smaller size, temperature stability, ease of chemical modification, lack of immunogenicity and toxicity, and lower cost of production,
Pierre Fechter +13 more
doaj +1 more source
International Journal of NanomedicineChao Cheng,1,* Minjia Sun,1– 3,* Jingjing Li,1,* Yitong Xue,1 Xia Cai,4 Jing Liu,1 Xiaolian Wang,5 Shouhong Xu,2 Youhua Xie,1 Junqi Zhang1 1MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease ...
Cheng C +9 more
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