Results 81 to 90 of about 14,594 (219)
Better estimation of protein-DNA interaction parameters improve prediction of functional sites
BMC Biotechnology, 2008 Background Characterizing transcription factor binding motifs is a common bioinformatics task. For transcription factors with variable binding sites, we need to get many suboptimal binding sites in our training dataset to get accurate estimates of free ...
O'Flanagan Ruadhan A +2 more
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Using Aptamers for Cancer Biomarker Discovery
Journal of Nucleic Acids, 2013 Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules.
Yun Min Chang +2 more
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Aptamers and SELEX in Chemistry & Biology
Chemistry & Biology, 2014 Nucleic acid aptamers, or simply aptamers, are oligonucleotides that bind specific ligands that vary from small molecules to proteins. An aptamer for a specific ligand is routinely identified through the process of systematic evolution of ligands by exponential enrichment, although some aptamers are found in nature as ligand-binding sites of special ...
Famulok, M., Mayer, G.
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Simple Methods and Rational Design for Enhancing Aptamer Sensitivity and Specificity
Frontiers in Molecular Biosciences, 2018 Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity and specificity. However, conventional SELEX (Systematic Evolution of Ligands by EXponential enrichment) methods may not necessarily produce aptamers of ...
Priya Kalra +6 more
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, 2019 Aptamers are short single-stranded oligonucleotide (DNA or RNA) molecules with the ability to bind to other molecules with high affinity and specificity. Nowadays, aptamers are used as biosensing molecules with broader applications, such as ribozymes (RNA enzyme molecules with catalytic activities); riboswitches (modulating translational activities ...
Laura Armero, Claudia Troncone Clemente
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NMR monitoring of the SELEX process to confirm enrichment of structured RNA
Scientific Reports, 2017 RNA aptamers are RNA molecules that bind to a target molecule with high affinity and specificity using uniquely-folded tertiary structures. RNA aptamers are selected from an RNA pool typically comprising up to 1015 different sequences generated by ...
Ryo Amano +6 more
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DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model
Molecular Therapy: Nucleic AcidsOligonucleotide aptamers are typically identified through a rigorous and time-consuming process known as systematic evolution of ligands by exponential enrichment (SELEX), which requires 20 to 30 iterative rounds to eliminate non/weak binding sequences ...
Xin Yang +18 more
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A Regulation-Based Security Evaluation Method for Data Link in Wireless Sensor Network
Journal of Computer Networks and Communications, 2014 This article presents a novel approach to the analysis of wireless sensor networks (WSN) security, based on the regulations intended for wireless communication devices.
Claudio S. Malavenda +2 more
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Specific Aspects of SELEX Protocol: Different Approaches for ssDNA Generation
Methods and ProtocolsBackground: Synthetic DNA aptamers are a class of molecules with potential applications in medicine, serving as molecular sensors or ligands for targeted drug delivery. Systematic evolution of ligands by exponential enrichment (SELEX) is a technology for
Alexandr Garanin +5 more
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ANTIOXIDANT ACTIVITY OF SELENIUM-CONTAINING BAKERY PRODUCTS [PDF]
Техника и технология пищевых производств, 2015 I In the process of technological quality control of foods containing antioxidants, it is necessary to estimate the total content of structurally or functionally related analytes.
Naumova N.L.
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