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The Role of Sema3C and R745A mutant on cell motility and microcapillary formation
2018Introduction: Class 3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the VEGF signaling pathway. Sema3 proteins convey their regulatory signals by binding to receptors neuropilins and plexins, which are located on the effector cell.
Valiulytė, Indrė +3 more
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Semaphorin 3c (SEMA3C) as a potential therapeutic target in breast cancer
Breast cancer (BCa) is a significant cause of cancer-related deaths among females globally. Approximately 45% of BCa patients develop treatment resistance or suffer from a lack of targeted therapies. Previously, we have shown that Semaphorin 3C (SEMA3C) is an autocrine growth factor that drives the growth and treatment resistance of various cancers ...openaire +1 more source
Background and Purpose: Hyperactivation of the mineralocorticoid receptor (MR) causes pro-inflammatory and pro-fibrotic actions, which are potential therapeutic targets of diabetic kidney disease (DKD). Finerenone (FIN), a novel non-steroidal mineralocorticoid receptor antagonist, attenuates vascular endothelial ...
Yajing Wang +9 more
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Yajing Wang +9 more
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Androgens i.e. testosterone (T) and dihydrotestosterone (DHT), have essential roles in the differentiation and growth of normal prostate cells, as well as in the progression of prostate cancer (PCa) cells. Androgen deprivation therapy (ADT) is an effective therapy for PCa patients, however, prostate tumor cells progress to a treatment-resistant stage ...
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2019
Glioma is the most common tumor in the central nervous system. The scientists try to find a way to inhibit tumor development and identify potential biomarkers for an earlier glioma prognosis. The aim of this study was to analyze the changes of SEMA3A, SEMA3C, SEMA3F, and NRP1 gene expression in different grade astrocytic glioma tumors and to identify ...
Kardonaitė, Deimantė +3 more
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Glioma is the most common tumor in the central nervous system. The scientists try to find a way to inhibit tumor development and identify potential biomarkers for an earlier glioma prognosis. The aim of this study was to analyze the changes of SEMA3A, SEMA3C, SEMA3F, and NRP1 gene expression in different grade astrocytic glioma tumors and to identify ...
Kardonaitė, Deimantė +3 more
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SEMAPHORIN 3C (SEMA3C) INHIBITOR THERAPEUTICS, METHODS, AND USES
2010ONG CHRISTOPHER J +3 more
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