Results 111 to 120 of about 2,273 (137)
High level of Sema3C is associated with glioma malignancy [PDF]
Diagnostic Pathology, 2015 Malignant gliomas are characterized by the tendency of cancerous glial cells to infiltrate into normal brain tissue, thereby complicating targeted treatment of this type of cancer. Recent studies suggested involvement of Sema3C (semaphorin 3C) protein in tumorigenesis and metastasis in a number of cancers.
Giedrius Steponaitis +2 more
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The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model [PDF]
International Journal of Molecular Sciences, 2019 Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis processes. Depending on the type and malignancy grade of the tumor, Sema3C function remains controversial.
Arunas Kazlauskas +2 more
exaly +3 more sources
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SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling
Prostate, 2021AbstractBackgroundCastration resistant prostate cancer progression is associated with an acquired intratumoral androgen synthesis. Signaling pathways that can upregulate androgen production in prostate tumor microenvironment are not entirely known. In this study, we investigate the potential effect of a secreted signaling protein named semaphorin 3C ...
Christopher Ong, Parvin Yenki
exaly +3 more sources
Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c [PDF]
Neuron, 2015 During neocortical development, neurons undergo polarization, oriented migration, and layer-type-specific differentiation. The transcriptional programs underlying these processes are not completely understood. Here, we show that the transcription factor Bcl11a regulates polarity and migration of upper layer neurons.
Pentao Liu +2 more
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Increased Expression of Sema3C Indicates a Poor Prognosis and Is Regulated by miR-142-5p in Glioma
Biological and Pharmaceutical Bulletin, 2020 Sema3C has been reported to promote glioma stem cells self-renewal and glioblastoma growth. However, the prognostic value and the regulatory mechanism for its abnormal expression in glioma remain poorly understood. In the current study, the immunohistochemistry results demonstrated that Sema3C was overexpressed in 169 of 216 (78.2%) interpretable ...
Zhang, Haidong +6 more
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SEMA3C promotes thyroid cancer via the Wnt/β-catenin pathway
Experimental Cell ResearchSemaphorin 3C (SEMA3C) regulates the progression of several tumors. However, the role of SEMA3C in thyroid cancer remains unknow. In the present study, SEMA3C was overexpressed or knocked down in thyroid cancer cell lines BCPAP and IHH-4. It was found that SEMA3C promoted the cell migration, invasion, and mesenchymal-epithelial transition (EMT) process.
Xiubo Lu
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Sema3C and Netrin-1 Differentially Affect Axon Growth in the Hippocampal Formation
Molecular and Cellular Neuroscience, 2000The interaction between outgrowing neurons and their targets is a central element in the development of the afferent and efferent connections of the hippocampal system. This requires that axonal growth cones recognize specific guidance cues in the appropriate target area.
A, Steup +8 more
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SEMA3C Depletion Promotes Neuroblastoma Metastatic Dissemination
Cancer Discovery, 2017Abstract A neuroblastoma chick embryo xenograft model recapitulates tumor initiation and dissemination.
exaly +2 more sources
International Journal of Developmental Neuroscience, 2020
AbstractNerve endings and terminal Schwann cells (TSCs) specifically and densely surround hair follicle at isthmus area, forming a neuromuscular‐junction‐like structure called lanceolate complex. The interplay between neuronal components and epidermis in this specialized structure enables hair to properly sense complex stimuli from environments ...
Hongbing Zhong, Xin-Hua Liao
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AbstractNerve endings and terminal Schwann cells (TSCs) specifically and densely surround hair follicle at isthmus area, forming a neuromuscular‐junction‐like structure called lanceolate complex. The interplay between neuronal components and epidermis in this specialized structure enables hair to properly sense complex stimuli from environments ...
Hongbing Zhong, Xin-Hua Liao
exaly +3 more sources
Upregulated SEMA3C in astrocytes contributes to Rett Syndrome phenotypes
Summary Astrocytes support neuronal function during development through secreted proteins, yet how astrocyte-secreted cues are altered in disease states and contribute to neurodevelopmental disorders remains poorly defined. Rett syndrome (RTT) is a regressive neurodevelopmental disorder characterized by motor, sensory,Krissy A. Lyon +4 more
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