Results 91 to 100 of about 7,206 (213)
Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells
Biomedicines, 2018 Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
doaj +1 more source
Movement Disorders, Volume 41, Issue 6, Page 1492-1501, June 2026.Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar +15 more
wiley +1 more source
Transmembrane semaphorins, forward and reverse signaling: Have a look both ways
, 2016 Semaphorins are signaling molecules playing pivotal roles not only as axon guidance cues, but are also involved in the regulation of a range of biological processes, such as immune response, angiogenesis and invasive tumor growth.
Tamagnone, Luca
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2017 The semaphorins and the plexins are a family of large, cysteine-rich proteins originally identified as regulators of axon growth and lymphocyte activation that are now known to provide motility and positional information for a number of cell and tissue ...
Hua Zhou +6 more
doaj +1 more source
The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada +8 more
wiley +1 more source
From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies
Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 170-188, June 2026.This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu +5 more
wiley +1 more source
The Journal of Dermatology, Volume 53, Issue 6, Page 867-879, June 2026.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji +7 more
wiley +1 more source
Biochemical bone biomarkers in plasma cell dyscrasias
British Journal of Haematology, Volume 208, Issue 6, Page 1909-1923, June 2026.Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador +4 more
wiley +1 more source
Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi +4 more
wiley +1 more source