Semaphorins and their receptors in olfactory axon guidance
, 1999 The mammalian olfactory system is capable of discriminating among a large variety of odor molecules and is therefore essential for the identification of food, enemies and mating partners.
Ruitenberg, M. J. +7 more
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Multifaceted Functional Role of Semaphorins in Glioblastoma [PDF]
, 2019 Glioblastoma (GBM) is the most malignant tumor type affecting the adult central nervous system. Despite advances in therapy, the prognosis for patients with GBM remains poor, with a median survival of about 15 months.
Cristiana Angelucci +2 more
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Abstract 410: Expression of class 3 semaphorins in prostate cancer and modulation by hypoxia
, 2010 Class 3 semaphorins are secreted proteins that act as guidance cues for migrating cells via their transmembrane receptors, plexins. Semaphorins have a role in cancer affecting tumour growth both directly and indirectly, by affecting angiogenesis.
Magali Williamson +4 more
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Cranial expression of class 3 secreted semaphorins and their neuropilin receptors
, 2003 The semaphorin family of chemorepellents and their receptors the neuropilins are implicated in a variety of cellular processes, including axon guidance and cell migration.
John K Chilton (16246364) +3 more
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The effect of aerobic exercise and psilocybin following methamphetamine induction on the gene expression of certain semaphorins in female Wistar rats [PDF]
Medical Laboratory JournalBackground: The purpose of the present study was to investigate the effect of aerobic exercise and psilocybin after methamphetamine induction on the gene expression of certain cerebral cortex semaphorins in female Wistar rats.
Fariba Rasannezhad +3 more
doaj
Role of Semaphorins in Angiogenesis and Innervation in Human Intervertebral Disc Degeneration
Global Spine Journal, 2014 Introduction Although the intervertebral disc (IVD) is considered the largest aneural structure within the human body, during degeneration nociceptive nerves are seen to accompany blood vessels into the IVD yet it remains unclear how this process occurs.
A. LA. Binch +7 more
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The association of semaphorins 3C, 5A and 6D with liver fibrosis stage in chronic hepatitis C.
PLoS ONE, 2018 Semaphorins are a diverse family of immunoregulators recently recognized to play a major role in various phases of immune responses. Their role in chronic viral hepatitis C (CHC) and contribution to the progression of liver disease is unknown. The aim of
Neven Papic +6 more
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Semaphorins in axon regeneration: developmental guidance molecules gone wrong?
, 2006 Semaphorins are developmental axon guidance cues that continue to be expressed during adulthood and are regulated by neural injury. During the formation of the nervous system, repulsive semaphorins guide axons to their targets by restricting and ...
Pasterkamp, R Jeroen, Verhaagen, J.
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Nature Communications, 2019 Semaphorin-plexin interactions regulate various developmental processes in Drosophila but the structural basis of these signaling events is unclear. Here, the authors present crystal structures of all Drosophila class 1 and 2 semaphorins, and elucidate ...
Daniel Rozbesky +7 more
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Role of semaphorins in the adult nervous system
, 2003 In the developing nervous system, extending axons are directed towards their appropriate targets by a myriad of attractive and repulsive guidance cues. Work in the past decade has significantly advanced our understanding of these molecules and has made ...
Wit, J. de +3 more
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