Results 61 to 70 of about 7,206 (213)
Emerging roles for semaphorins in neural regeneration
, 2001 Progressive axon outgrowth during neural development contrasts with the failure of regenerative neurite growth in the mature mammalian central nervous system (CNS). During neuroembryogenesis, spatiotemporal patterns of repellent and attractant activities
Pasterkamp, R.J. +3 more
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Functional diversity and mechanisms of action of the semaphorins [PDF]
, 2008 The second EMBO workshop on 'Semaphorin function and mechanisms of action', held in the gorgeous surroundings of the 12th Century Abbaye des Vaulx de Cernay near Paris, France this May, brought together a wide range of scientists working in diverse ...
Eickholt, B J, B. J. Eickholt
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Semaphorins in immune cell function, inflammatory and infectious diseases
, 2023 The Semaphorin family is a group of proteins studied broadly for their functions in nervous systems. They consist of eight subfamilies ubiquitously expressed in vertebrates, invertebrates, and viruses and exist in membrane-bound or secreted forms ...
Rony Thomas, Xi Yang
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Involvement of semaphorins in autoimmunity
Japanese Journal of Clinical Immunology, 2005 Semaphorins were identified originally as guidance cues for developing axons. However, it is becoming clear that several semaphorins are crucially involved in the immune system. For instance, Sema4D (CD100) enhances activation of B cells and dendritic cells, and Sema4A is involved in T cell priming and Th1/Th2 regulation. In addition, recent cumulative
TAKAMATSU, Hyota, KUMANOGOH, Atsushi
openaire +3 more sources
Neurodevelopmental Phenotypes and Brain Anomalies in Individuals With Heterozygous SEMA6A Variants
Clinical Genetics, EarlyView.SEMA6A plays a role in cell migration and axon guidance in the developing central nervous system. Phenotypes seen in eleven individuals heterozygous for SEMA6A variants included developmental delay, intellectual disability, autism/autistic behaviors, behavioral abnormalities, attention disorders, hypotonia, and brain anomalies.
Evan Burchfiel +27 more
wiley +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
The functions of Semaphorins in the neural development
, 2010 During embryogenesis, axons reach their specific targets correctly to form the complex neural network found in the mature functional nervous system.
Masahiko, Taniguchi
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Semaphorin 3A and Class 4 Semaphorins in Tooth Innervation and Development [PDF]
, 2014 Background: Dental trigeminal axon elongation, navigation and patterning occur in a controlled manner that is intimately linked to tooth shape formation and cell differentiation.
Shrestha, Anjana
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THE ROLES AND MECHANISMS OF SEMAPHORINS ACTIVITY IN CANCER
, 2023 Throughout embryonic and fetal development, semaphorins communicate via Plexin receptors to serve as directional cues. Their modulation of tumor angiogenesis, tumor development, cancer cell invasiveness, and metastasis is a relatively new discovery in ...
Dr.Nand Kumar Kashyap, Dr. K.S.V.K.S.Madhavi Rani, Dr. Ramesh babu, Dr. kodipad shafahed, Dr.Prashanti Chitrapu, Dr. T Ramesh
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Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source