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"Brain doping" substances: prohibited or not in sports? [PDF]

open access: yesBiol Sport
Pokrywka A   +7 more
europepmc   +1 more source
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Effects of Semax in the Models of Acute Stress

Российский физиологический журнал им  И  М  Сеченова, 2023
Acute stress exposure causes a cascade of neurochemical reactions, leading, in particular, to a change in behavior and increased tolerance to pain in humans and animals. ACTH/MSH-like peptides play an important role in regulating the body’s response to stressful exposures.
N. Yu. Glazova   +9 more
openaire   +1 more source

Therapy of Peptic Ulcer with Semax Peptide

Bulletin of Experimental Biology and Medicine, 2002
Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers.
I O, Ivanikov   +4 more
openaire   +2 more sources

Synthesis of tritium-labeled Semax

Radiochemistry, 2006
The tert-butyloxycarbonyl derivative of Met-Glu-His-Phe-Pro-Gly was prepared and condensed with either unsaturated or labeled proline. The unsaturated peptide protected by the tert-butyloxycarbonyl group was hydrogenated with gaseous tritium in the presence of a catalyst.
V. P. Shevchenko   +7 more
openaire   +1 more source

Effect of Modification of the N-Terminal Region of Semax on the Expression of Nootropic Effect of Semax Analogs

Biology Bulletin, 2005
A comparative study of nootropic activity of semax (MEHFPGP), an analog of ACTH 4-10 , and some of its derivatives, in which the N-terminal methionine was modified or substituted with other amino acid residues, was performed. The effect of these peptides on learning of albino rats in tests with positive (food) and negative (pain) reinforcement was ...
N. Yu. Glazova   +6 more
openaire   +1 more source

Effect of semax and semax-heparin mixture on isolated heart activity after total ischemia in rats

Bulletin of Experimental Biology and Medicine, 1999
Semax administered after 40-min total ischemia of isolated heart improved the recovery of heart rate and reduced myocardial contracture. When administered prior to ischemia, Semax exerted a negative effect on recovery of heart contractility. Semax-heparin mixture significantly improved the recovery of cardiac indices (end-diastolic pressure, heart rate,
A. V. Orlov   +5 more
openaire   +1 more source

Effects of Semax on the Default Mode Network of the Brain

Bulletin of Experimental Biology and Medicine, 2018
The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resonance imaging (resting state fMRI). The study was carried out on two groups of healthy volunteers (11 men and 13 women aged 43.9±9.5 years). Resting state fMRI was carried out 3 times: directly before and 5 and 20 min after
I S, Lebedeva   +6 more
openaire   +2 more sources

SEMAX - APPLICATION PROSPECTS (brief overview message)

Clinical Medicine and Pharmacology, 2021
A brief overview report on the materials of domestic research, as a priority, shows a brief history of the study of regulatory peptides, in particular Semax. The need to continue scientific research in this direction is due, in addition to somatoform and psychosomatic diseases, complications of var-ious diseases in the form of memory impairment, a ...
Elena Belyaeva, K. Hadarceva
openaire   +1 more source

Effect of semax heptapeptide on the human electroencephalogram

Bulletin of Experimental Biology and Medicine, 1996
The effect of the new regulatory peptide Semax (ACTH4–10 fragment) on the electroencephalogram of a healthy person was studied. Semax was administered at 0.5 mg/kg intranasally in 9 volunteers without causing any nervous system pathology. The control group comprised 6 examinees treated in the same way with distilled water.
M. V. Koroleva   +4 more
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