Results 121 to 130 of about 408 (173)

Therapy of Peptic Ulcer with Semax Peptide

Bulletin of Experimental Biology and Medicine, 2002
Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers.
I O, Ivanikov, M E, Brekhova, G E, Samonina, N F, Myasoedov, I P, Ashmarin   +4 more
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Synthesis of tritium-labeled Semax

Radiochemistry, 2006
The tert-butyloxycarbonyl derivative of Met-Glu-His-Phe-Pro-Gly was prepared and condensed with either unsaturated or labeled proline. The unsaturated peptide protected by the tert-butyloxycarbonyl group was hydrogenated with gaseous tritium in the presence of a catalyst.
V. P. Shevchenko, I. Yu. Nagaev, L. Yu. Alfeeva, L. A. Andreeva, P. A. Klimova, K. V. Shevchenko, A. V. Malkin, N. F. Myasoedov   +7 more
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Effect of Modification of the N-Terminal Region of Semax on the Expression of Nootropic Effect of Semax Analogs

Biology Bulletin, 2005
A comparative study of nootropic activity of semax (MEHFPGP), an analog of ACTH 4-10 , and some of its derivatives, in which the N-terminal methionine was modified or substituted with other amino acid residues, was performed. The effect of these peptides on learning of albino rats in tests with positive (food) and negative (pain) reinforcement was ...
N. Yu. Glazova, E. A. Sebentsova, N. G. Levitskaya, L. A. Andreeva, L. Yu. Alfeeva, A. A. Kamenskii, N. F. Myasoedov   +6 more
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Effect of semax and semax-heparin mixture on isolated heart activity after total ischemia in rats

Bulletin of Experimental Biology and Medicine, 1999
Semax administered after 40-min total ischemia of isolated heart improved the recovery of heart rate and reduced myocardial contracture. When administered prior to ischemia, Semax exerted a negative effect on recovery of heart contractility. Semax-heparin mixture significantly improved the recovery of cardiac indices (end-diastolic pressure, heart rate,
A. V. Orlov, A. E. Khomutov, I. V. Mukhina, Yu. B. Zimin, S. B. Parin, D. V. Kozin   +5 more
openaire   +1 more source

Effect of semax heptapeptide on the human electroencephalogram

Bulletin of Experimental Biology and Medicine, 1996
The effect of the new regulatory peptide Semax (ACTH4–10 fragment) on the electroencephalogram of a healthy person was studied. Semax was administered at 0.5 mg/kg intranasally in 9 volunteers without causing any nervous system pathology. The control group comprised 6 examinees treated in the same way with distilled water.
M. V. Koroleva, E. E. Meizerov, V. N. Nezavibat'ko, A. A. Kamenskii, V. A. Dubynin   +4 more
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Functional Connectomic Approach to Studying Selank and Semax Effects

Doklady Biological Sciences, 2020
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs included amygdala (one of the key regions for the regulation of anxiety) and dorsolateral prefrontal ...
Ya R, Panikratova, I S, Lebedeva, O Yu, Sokolov, A D, Rumshiskaya, D A, Kupriyanov, N V, Kost, N F, Myasoedov   +6 more
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Analgesic action of the new drug Semax

Bulletin of Experimental Biology and Medicine, 1996
Intranasal administration of the new regulatory peptide Semax (0.5 mg/kg) relieves migraine headache and pain caused by dental plexalgia. The analgesic effect of Semax is due to spasmolytic and general regulatory activities but not to its influence on pain sensitivity system.
M. V. Koroleva, E. E. Meizerov, V. N. Nezavibat'ko, A. A. Kamenskii, V. A. Dubynin, Yu. B. Yakovlev   +5 more
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Semax as a Universal Drug for Therapy and Research

Biology Bulletin, 2018
In this review, based on published experimental and clinical data (1980‒2016), a comparative analysis of the structures and effects of Semax (peptide drug) and its analogue fragments was carried out. The effect of these oligopeptides on various body systems is examined.
S. V. Koroleva, N. F. Myasoedov
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Semax prevents functional impairments of avoidance response in rats

Doklady Biological Sciences, 2013
ACTH/MSHrelated peptides, known as melanocortins, play an important role in regulation of manyfunctions in the body, including CNS. Among melanocortins, Semax is very prominent because it is anootropic analogue of ACTH (4–10) with prolongedaction [1].
A N, Inozemtsev, A E, Agapitova, S B, Bokieva, N G, Levitskaya, A A, Kamenskii, N F, Myasoedov   +5 more
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Semax prevents learning and memory inhibition by heavy metals

Doklady Biological Sciences, 2016
Separate and joint effect of Semax, ascorbic acid, lead diacetate, and ammonium molybdate on avoidance conditioning in rats was studied. It was established that the heavy metal salts inhibited the avoidance response, and the peptide counteracted this inhibition as strongly as ascorbic acid or to a comparable degree.
A N, Inozemtsev, S B, Bokieva, O V, Karpukhina, K Z, Gumargalieva, A A, Kamensky, N F, Myasoedov   +5 more
openaire   +2 more sources