Results 131 to 140 of about 408 (173)

Specific binding of semax in different regions of the rat brain

Doklady Biological Sciences, 2006
Highly specific binding of Semax had been found in hippocampus and cerebellum ( K A is 104.6 and 106.7 nM, respectively), whereas in the basal ganlia and cortex, we have found only nonspecific binding. Semax, as a nootropic drug, can increase the acuity of vision, enhance attention, regulate processes of learning and memory formation [1‐3]. It is known
T V, V'yunova, K V, Shevchenko, V P, Shevchenko, M Yu, Bobrov, V V, Bezuglov, N F, Myasoedov   +5 more
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In Vivo Efficiency of Semax in Global Cerebral Ischemia

Bulletin of Experimental Biology and Medicine, 1999
The efficiency of neuropeptide preparation Semax was studied on an animal model of global cerebral ischemia caused by irreversible bilateral occlusion of the common carotid arteries. Semax significantly alleviated neurological deficit and slightly improved postischemic survival.
E I Gusev, V I Skvortsova, V S Kuzenkov
exaly   +2 more sources

[Chronotropic activity of semax].

Eksperimental'naia i klinicheskaia farmakologiia, 2008
The chronic administration of nootropic drug Semax, a peptide analog of ACTH (4-10), normalized the circadian locomotor rhythm in rats (with an increase in its amplitude, a shift in the acrophase, and a change of the spectral characteristics) and reduced the integral chronobiological index.
E B, Arushanian, A V, Popov
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Effect of semax on homeostasis of gastric mucosa in albino rats

Bulletin of Experimental Biology and Medicine, 2000
The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers ...
S E, Zhuikova, E A, Smirnova, Z V, Bakaeva, G E, Samonina, I P, Ashmarin   +4 more
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Effects of semax against the background of dopaminergic receptor blockade with haloperidol

Bulletin of Experimental Biology and Medicine, 2006
We studied the neurotropic effects of ACTH(4-10) analog semax against the background of dopaminergic receptors blockade with haloperidol. Intranasal administration of semax (0.05, 0.2, and 0.6 mg/kg) produced virtually no effect on disturbances of orientation and exploratory reactions and motor activity caused by intraperitoneal injection of 0.2 mg/kg ...
E A, Sebentsova, N G, Levitskaya, L A, Andreeva, L Yu, Alfeeva, A A, Kamenskii, N F, Myasoedov   +5 more
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Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery

Bulletin of Experimental Biology and Medicine, 2003
One-hour immobilization stress considerably disturbed microcirculation in the mesentery: blood flow in small mesenteric vessels decreased or stopped and numerous hemorrhages appeared. Lymphatic vessels lost spontaneous activity and did not respond to norepinephrine.
G N, Kopylova, E A, Smirnova, L Ts, Sanzhieva, B A, Umarova, T V, Lelekova, G E, Samonina   +5 more
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The efficacy of semax in the tretament of patients at different stages of ischemic stroke

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018
To evaluate the efficacy of semax and timing of rehabilitation on the dynamics of plasma BDNF levels, motor performance, and Barthel index score in patients after ischemic stroke (IS).One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined.
E I, Gusev, M Yu, Martynov, E V, Kostenko, L V, Petrova, S N, Bobyreva   +4 more
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[Antihypoxic and antiamnesic effects of mexidol and semax].

Eksperimental'naia i klinicheskaia farmakologiia, 2010
Upon single administration, mexidol and semax only in doses of 100 and 0.05 mg/kg, respectively, produced an antihypoxic effect on mice in the altitude chamber and hermetic chamber tests. Preventive course administration of mexidol and semax for 6 days gave significant antihypoxic effect on the model of acute hypobaric hypoxia in mice in doses of 75 ...
Vik V, Iasnetsov, T A, Voronina
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Effects of Semax on Dopaminergic and Serotoninergic Systems of the Brain

Doklady Biological Sciences, 2004
K O, Eremin, V S, Kudrin, I A, Grivennikov, N F, Miasoedov, K S, Rayevsky   +4 more
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[Use of semax at a follow-up of patients with posthypoxic encephalopathy].

Anesteziologiia i reanimatologiia, 1999
Effect of a neuropeptide semax is studied in 73 patients with various symptoms of posthypoxic encephalopathy in remote period. Fourteen of these patients developed a persistent vegetative state. The therapy was effective in patients with mnestic disorders; the drug effect was potentiated by an adaptogen oxiterm and by supraorbital electrophoresis.
G V, Alekseeva, N A, Bottaev, V V, Goroshkova   +2 more
openaire   +1 more source