Results 111 to 120 of about 258 (157)

Functional Connectomic Approach to Studying Selank and Semax Effects

Doklady Biological Sciences, 2020
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs included amygdala (one of the key regions for the regulation of anxiety) and dorsolateral prefrontal ...
Ya R, Panikratova, I S, Lebedeva, O Yu, Sokolov, A D, Rumshiskaya, D A, Kupriyanov, N V, Kost, N F, Myasoedov   +6 more
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Analgesic action of the new drug Semax

Bulletin of Experimental Biology and Medicine, 1996
Intranasal administration of the new regulatory peptide Semax (0.5 mg/kg) relieves migraine headache and pain caused by dental plexalgia. The analgesic effect of Semax is due to spasmolytic and general regulatory activities but not to its influence on pain sensitivity system.
M. V. Koroleva, E. E. Meizerov, V. N. Nezavibat'ko, A. A. Kamenskii, V. A. Dubynin, Yu. B. Yakovlev   +5 more
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Semax as a Universal Drug for Therapy and Research

Biology Bulletin, 2018
In this review, based on published experimental and clinical data (1980‒2016), a comparative analysis of the structures and effects of Semax (peptide drug) and its analogue fragments was carried out. The effect of these oligopeptides on various body systems is examined.
S. V. Koroleva, N. F. Myasoedov
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Semax prevents functional impairments of avoidance response in rats

Doklady Biological Sciences, 2013
ACTH/MSHrelated peptides, known as melanocortins, play an important role in regulation of manyfunctions in the body, including CNS. Among melanocortins, Semax is very prominent because it is anootropic analogue of ACTH (4–10) with prolongedaction [1].
A N, Inozemtsev, A E, Agapitova, S B, Bokieva, N G, Levitskaya, A A, Kamenskii, N F, Myasoedov   +5 more
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In vivo efficiency of Semax in global cerebral ischemia

Bulletin of Experimental Biology and Medicine, 1999
The efficiency of neuropeptide preparation Semax was studied on an animal model of global cerebral ischemia caused by irreversible bilateral occlusion of the common carotid arteries. Semax significantly alleviated neurological deficit and slightly improved postischemic survival.
V S Kuzenkov, V I Skvortsova, V B Koshelev   +2 more
exaly   +2 more sources

Semax prevents learning and memory inhibition by heavy metals

Doklady Biological Sciences, 2016
Separate and joint effect of Semax, ascorbic acid, lead diacetate, and ammonium molybdate on avoidance conditioning in rats was studied. It was established that the heavy metal salts inhibited the avoidance response, and the peptide counteracted this inhibition as strongly as ascorbic acid or to a comparable degree.
A N, Inozemtsev, S B, Bokieva, O V, Karpukhina, K Z, Gumargalieva, A A, Kamensky, N F, Myasoedov   +5 more
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Specific binding of semax in different regions of the rat brain

Doklady Biological Sciences, 2006
Highly specific binding of Semax had been found in hippocampus and cerebellum ( K A is 104.6 and 106.7 nM, respectively), whereas in the basal ganlia and cortex, we have found only nonspecific binding. Semax, as a nootropic drug, can increase the acuity of vision, enhance attention, regulate processes of learning and memory formation [1‐3]. It is known
T V, V'yunova, K V, Shevchenko, V P, Shevchenko, M Yu, Bobrov, V V, Bezuglov, N F, Myasoedov   +5 more
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[Chronotropic activity of semax].

Eksperimental'naia i klinicheskaia farmakologiia, 2008
The chronic administration of nootropic drug Semax, a peptide analog of ACTH (4-10), normalized the circadian locomotor rhythm in rats (with an increase in its amplitude, a shift in the acrophase, and a change of the spectral characteristics) and reduced the integral chronobiological index.
E B, Arushanian, A V, Popov
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Effect of semax on homeostasis of gastric mucosa in albino rats

Bulletin of Experimental Biology and Medicine, 2000
The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers ...
S E, Zhuikova, E A, Smirnova, Z V, Bakaeva, G E, Samonina, I P, Ashmarin   +4 more
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Effects of semax against the background of dopaminergic receptor blockade with haloperidol

Bulletin of Experimental Biology and Medicine, 2006
We studied the neurotropic effects of ACTH(4-10) analog semax against the background of dopaminergic receptors blockade with haloperidol. Intranasal administration of semax (0.05, 0.2, and 0.6 mg/kg) produced virtually no effect on disturbances of orientation and exploratory reactions and motor activity caused by intraperitoneal injection of 0.2 mg/kg ...
E A, Sebentsova, N G, Levitskaya, L A, Andreeva, L Yu, Alfeeva, A A, Kamenskii, N F, Myasoedov   +5 more
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