Ribosomal Synthesis of Topologically Defined Thioisoindole-Bridged Bicyclic Peptides. [PDF]
Angew Chem Int Ed EnglA flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Zhang Y, Vinogradov AA, Sun Y, Suga H.
europepmc +3 more sources
Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders. [PDF]
ChemMedChemA partial proteolysis targeting chimera (PROTAC) library bearing achiral phenyl dihydrouracil cereblon ligands is prepared. It is then applied to the rapid development of a full PROTAC library targeting Bruton's tyrosine kinase, which can be directly used for screening.
Almodóvar-Rivera CM +5 more
europepmc +2 more sources
Kinetics study of hydrazodicarbonamide synthesis reaction [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2013 In this study, the kinetics of hydrazodicarbonamide (HDCA) synthesis reaction was investigated. Hydrazodicarbonamide is prepared by reaction of urea and hydrazine in acidic medium. Synthesis of HDCA from urea and hydrazine is a two steps reaction.
Bakeri Gh., Rahimnejad M.
doaj +1 more source
Journal of Toxicology, 2022 The study was conducted to evaluate the toxicological effects, functional observation battery tests, and sexual maturity of semicarbazide oral gavage administration to juvenile Sprague-Dawley rats for 70 days at 0, 15, 30, and 60 mg/kg/day weaning to ...
Vijaykumar Malashetty +2 more
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2022 The title polymer, [Cu(SO4)(CH5N3O)2]n, has been synthesized from aqueous solutions of CuSO4 and semicarbazide. In the crystal structure, the CuII atoms are chelated by two neutral semicarbazide molecules through the oxygen atom and a nitrogen atom of ...
Galiya Tadjieva +4 more
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A Mechanistic Study on the Non-genotoxic Carcinogenicity of the Food Contaminant Semicarbazide
SURE Journal: (Science Undergraduate Research Experience Journal), 2020 Semicarbazide was brought to the forefront of scientific discussions by the scientific community in the early 2000’s as the substance was discovered in several food products from both synthetic and natural sources.
Daniel P. Fitzpatrick
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Synthesis of 1,6-bis(semicarbazide)hexanes and 1,6-bis(1,2,4-triazol-5-one)hexanes and their antiproliferative and antimicrobial activity [PDF]
Journal of the Serbian Chemical Society, 2012 A series of 1,6-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-on-4- yl)hexanes (3a-g) were synthesized by the cyclization reaction of 1,6-bis(1- substituted-semicarbazide-4-yl)hexanes (2a-g) in alkaline medium.
Pitucha M. +3 more
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Azapeptides as an Efficient Tool to Improve the Activity of Biologically Effective Peptides
Future Pharmacology, 2022 Peptides are highly potent biological active compounds with excellent selectivity and binding, but they have some drawbacks (e.g., low stability in vivo because of the enzymatic degradation, and fast elimination).
Karima Tarchoun +2 more
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Influence of semicarbazide on the peroxidation processes and Lewis carcinoma growth in mice [PDF]
The Ukrainian Biochemical Journal, 2014 Effects of various doses of semicarbazide on Lewis carcinoma metastasing and peroxidation processes in С57В1 mice have been investigated. In the animals with inoculated Lewis carcinoma, the semicarbazide in the dose of 1/120 LD50 had practical influence ...
L. M. Petrun
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Residue analyses and exposure assessment of the Irish population to nitrofuran metabolites from different food commodities in 2009–2010 [PDF]
, 2013 peer-reviewedAn exposure assessment to nitrofuran residues was performed for three human populations (adults, teenagers and children), based on residue analyses of foods of animal origin (liver, honey, eggs and aquaculture) covering the 2-year period ...
Conroy, Emma-Rose +4 more
core +1 more source