Results 141 to 150 of about 51,520 (299)

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype [PDF]

, 2015
Nicolás Herranz, Suchira Gallage, Massimiliano Mellone, Torsten Wüestefeld, Sabrina Klotz, Christopher J. Hanley, Selina Raguz, Juan Carlos Acosta, Andrew J. Innes, Ana Banito, Athena Georgilis, Alex Montoya, Katharina Wolter, Gopuraja Dharmalingam, Peter Faull, Thomas Carroll, Juan Pedro Martı́nez-Barberá, Pedro R. Cutillas, Florian Reisinger, Mathias Heikenwälder, Richard Miller, Dominic J. Withers, Lars Zender, Gareth J. Thomas, Jesús Gil   +24 more
openalex   +1 more source

Table S6 from The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

, 2023
Juliane L. Buhl, Florian Selt, Thomas Hielscher, Romain Guiho, Jonas Ecker, Felix Sahm, Johannes Ridinger, Dennis Riehl, Diren Usta, Britta Ismer, Alexander C. Sommerkamp, Juan Pedro Martı́nez-Barberá, Annika K. Wefers, Marc Remke, Daniel Picard, Stefan Pusch, Jan Gronych, Ina Oehme, Cornelis M. van Tilburg, Marcel Kool, Daniela Kühn, David Capper, Andreas von Deimling, Martin U. Schuhmann, Christel Herold‐Mende, Andrey Korshunov, Tilman Brummer, Stefan M. Pfister, David Jones, Olaf Witt, Till Milde   +30 more
openalex   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

Corrigendum: The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

The interplay between obesity, immunosenescence, and insulin resistance

Immunity & Ageing
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging.
Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery, Hamid Zand   +4 more
doaj   +1 more source

c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors [PDF]

, 2017
Alspach, Elise, Arthur, Laura L, Flanagan, Kevin C, Parajuli, Shankar, Pazolli, Ermira, Ren, Qihao, Stewart, Sheila A, Tapia, Roberto   +7 more
core   +2 more sources

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

A narrative review of therapy-induced senescence in cancer: mechanisms, immune interplay, and therapeutic opportunities

Journal of the Egyptian National Cancer Institute
Therapy-induced senescence (TIS) has emerged as a pivotal mechanism in cancer therapy, exerting both tumor-suppressive and tumor-promoting effects.
Henry Sutanto, Alfan Ahkami, Deasy Fetarayani, Pradana Zaky Romadhon   +3 more
doaj   +1 more source

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype [PDF]

, 2023
Máté Maus, Vanessa López-Polo, Lídia Mateo, Miguel Lafarga, Mònica Aguilera, Eugenia De Lama, Kathleen Meyer, Anna Solà, Cecilia López‐Martínez, Inés López-Alonso, Marc Guasch-Piqueras, Fernanda Hernández‐González, Selim Chaib, Miguel Rovira, Mayka Sánchez, Rosa Faner, Àlvar Agustí, Rodrigo Diéguez‐Hurtado, Sagrario Ortega, Anna Manonelles, Stefan Engelhardt, Freddy Monteiro, Camille Stephan‐Otto Attolini, Neus Prats, Guillermo M. Albaiceta, Josep M. Cruzado, Manuel Serrano   +26 more
openalex   +1 more source