Results 111 to 120 of about 8,472,936 (269)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression [PDF]

Background: Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated as potential oncogenic drivers ...
Tichy, Boris, Stoiber, S., Aufinger, Astrid,, Sternberg, Christina, Tichy, B., Sternberg, C., Hoegler, Sandra, Theurillat, Jean-Philippe,, Tichy, Boris,, Högler, Sandra, Tomberger, Martina,, Moriggl, Richard,, Redmer, T., Schlederer, M., Lindner, Desiree, Redmer, Torben, Ziegler, R., Bolis, Marco,, Kodajova, Petra, Oberhuber, Monika, Harbusch, Nora S.,, Sternberg, Christina,, Persson, Jenny L., Neubauer, Heidi A, Merkel, Olaf, Pospisilova, Sarka, Ziegler, Roman,, Oberhuber, Monika,, Sternberg, Felix,, Neubauer, Heidi A.,, Kodajova, Petra,, Bystry, Vojtech, Ziegler, Roman, Lagger, Sabine,, Garces de Los Fayos Alonso, I., Lindner, Desiree,, Mathas, Stephan, Moriggl, R., Theurillat, J.P., Strobl, Birgit, Garces de los Fayos Alonso, Ines,, Persson, Jenny L.,, Stoiber, Stefan, Högler, S., Högler, Sandra,, Merkel, O., Pospisilova, Sarka,, Theurillat, Jean-Philippe, Harbusch, Nora S., Bolis, M., Raigel, Martin,, Lindner, D., Garces de los Fayos Alonso, Ines, Mathas, S., Mathas, Stephan,, Limberger, Tanja, Tomberger, M., Persson, J.L., Schlederer, Michaela, Oberhuber, M., Harbusch, Nora S, Miranda, Sara,, Moriggl, Richard, Pospisilova, S., Persson, Jenny L, Kodajova, P., Aufinger, A., Probst, C., Sternberg, F., Aufinger, Astrid, Miranda, Sara, Stoiber, Stefan,, Strobl, Birgit,, Strobl, B., Sternberg, Felix, Probst, Clara,, Bystry, Vojtech,, Redmer, Torben,, Aberger, F., Egger, Gerda,, Trachtova, Karolina,, Limberger, Tanja,, Harbusch, N.S., Bolis, Marco, Lagger, Sabine, Egger, Gerda, Raigel, M., Kenner, L., Aberger, Fritz, Trachtova, K., Neubauer, H.A., Aberger, Fritz,, Bystry, V., Egger, G., Raigel, Martin, Kenner, Lukas,, Probst, Clara, Tomberger, Martina, Schlederer, Michaela,, Neubauer, Heidi A., Lagger, S., Kenner, Lukas, Miranda, S., Merkel, Olaf,, Trachtova, Karolina, Limberger, T.   +105 more
core   +2 more sources

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Inflammasome activation and accelerated immune aging in autoimmune disorders

Frontiers in Aging
Autoimmune diseases, particularly those with early onset such as systemic lupus erythematosus, juvenile idiopathic arthritis, and type 1 diabetes, are paradoxically characterized by molecular and cellular features typically associated with aging.
Rahul Mittal, Rahul Mittal, Danay Saavedra, Mannat Mittal, Joana R. N. Lemos, Joana R. N. Lemos, Khemraj Hirani, Khemraj Hirani   +7 more
doaj   +1 more source

The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation

Aging, 2023
Huna, Anda, Martin, Nadine, Bernard, David   +2 more
openaire   +3 more sources

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Corrigendum: The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

Frontiers in Molecular Biosciences
Cell senescence is triggered by stressful stimuli, including telomere attrition, genotoxic agents, and strong mitogenic signals. This state is characterized by proliferation arrest and acquisition of a senescence-associated secretory phenotype. Senescent
Eliana Chacón, Guillermo Grünwaldt, Inés Marmisolle, Jennyfer Martínez, Celia Quijano   +4 more
doaj   +1 more source