Results 151 to 160 of about 1,495 (185)

Calcium (Ca²⁺) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS). [PDF]

NPJ Aging
Puebla-Huerta A, Huerta H, Quezada-Gutierez C, Morgado-Cáceres P, Casanova-Canelo C, Niño SA, Linsambarth S, Díaz-Rivera O, López-Domínguez JA, Rodríguez-López S, González-Reyes JA, Bustos G, Silva-Pavez E, Lovy A, Quiroz G, González-Seguel C, Salas-Huenuleo E, Kogan MJ, Molgó J, Zakarian A, Villalba JM, Gonzalez-Billault C, Calì T, Ahumada-Castro U, Cárdenas JC.   +24 more
europepmc   +1 more source

Killing wisely: precision senolytics in the age of frailty. [PDF]

Genes Dev
Barthet VJA, Lowe SW.
europepmc   +1 more source

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

Cell Metabolism, 2021
Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embryogenesis, wound healing, inflammation, and many age ...
Christopher D Wiley, Jose Alberto Lopez-Dominguez, Fatouma Alimirah   +2 more
exaly   +5 more sources

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Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

Science, 2021
Selective destruction of senescent cells Senescent cells are associated with a variety of age-related medical conditions and thus have been proposed as potential targets for therapy, but we do not yet have a full understanding of the underlying mechanisms. Johmura et al. used RNA interference to screen for
Yoshikazu Johmura, Takehiro Yamanaka, Satotaka Omori   +2 more
exaly   +3 more sources

A senolysis-based theragnostic prodrug strategy towards chronic renal failure

Chemical Science, 2022
Here, we report a senescence-associated β-galactosidase activatable theragnostic prodrug to pertinently treat chronic renal failure (CRF) in mice with the aid of fluorescence-guided senolysis, providing a creative molecular approach to CRF therapy.
Yihe Song, Li Xinming, Donglei Shi
exaly   +3 more sources

Recent Advances in Senolysis for Age-Related Diseases

Physiology, 2023
Cellular senescence plays a central role in aging and geriatric diseases. Senolysis is a promising new strategy that selectively kills and eliminates senescent cells to control aging. To date, various senolytic drugs have been discovered and shown efficacy. This review highlights how we can benefit from senolysis.
Sae Aratani, Makoto Nakanishi
exaly   +3 more sources

BCL-2 proteins in senescence: beyond a simple target for senolysis?

Nature Reviews Molecular Cell Biology, 2023
BCL-2 and related proteins are major regulators of apoptosis that have emerged as promising targets for the elimination senescent cells (or ‘senolysis’) to improve age-related diseases and promote healthy ageing. However, seminal observations and recent findings shed light on non-apoptotic roles of BCL-2 proteins in the regulation of cellular ...
Nadine Martin, Nikolay Popgeorgiev, David Bernard   +2 more
exaly   +4 more sources

Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis

International Journal of Molecular Sciences, 2022
Within the present study we proposed a novel approach for senolysis based on the simultaneous disturbance of the several homeostasis-maintaining systems in senescent cells including intracellular ionic balance, energy production and intracellular utilization of damaged products.
Pavel Deryabin, Aleksandra Borodkina
exaly   +3 more sources