Results 161 to 170 of about 1,495 (185)

Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides [PDF]

Cellular and Molecular Life Sciences, 2021
Abstract Targeted elimination of senescent cells, senolysis, is one of the core trends in the anti-aging therapy. Cardiac glycosides were recently proved to be a broad-spectrum senolytics. Here we tested senolytic properties of cardiac glycosides towards human mesenchymal stem cells (hMSCs). Cardiac glycosides had no senolytic ability
Alla N Shatrova, Aleksandra Borodkina
exaly   +3 more sources

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes [PDF]

Cell Metabolism, 2019
Type 2 diabetes (T2D) is an age-related disease. Although changes in function and proliferation of aged β cells resemble those preceding the development of diabetes, the contribution of β cell aging and senescence remains unclear. We generated a β cell senescence signature and found that insulin resistance accelerates β cell senescence leading to loss ...
Cristina Aguayo-Mazzucato, Ayush Midha, Jan M Van Deursen   +2 more
exaly   +3 more sources

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Feedback amplification of senolysis using caspase-3-cleavable peptide-doxorubicin conjugate and 2DG

Journal of Controlled Release, 2022
Therapy-induced senescence (TIS), a common outcome of current cancer therapy, is a known cause of late recurrence and metastasis and thus its eradication is crucial for therapy success. In this study, we introduced a conceptually novel strategy combining radiation-induced apoptosis-targeted chemotherapy (RIATC) with an effective glycolysis inhibitor, 2-
Jong Cheol Lee, Na Kyeong Lee, Seong Who Kim   +2 more
exaly   +3 more sources

cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

Nature Cancer, 2022
Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a ...
Liqin Wang, Haojie Jin, Fleur Jochems, Siying Wang, Cor Lieftink, Isabel Mora Martinez, Giulia De Conti, Finn Edwards, Rodrigo Leite de Oliveira, Arnout Schepers, Yangyang Zhou, Jiaojiao Zheng, Wei Wu, Xingling Zheng, Shengxian Yuan, Jing Ling, Kathy Jastrzebski, Matheus Dos Santos Dias, Ji-Ying Song, Patrick N. H. Celie, Hideo Yagita, Ming Yao, Weiping Zhou, Roderick L. Beijersbergen, Wenxin Qin, René Bernards   +25 more
openaire   +4 more sources

Senolysis Reduces Senescence in Veins and Cancer Cell Migration

Advanced Therapeutics, 2021
AbstractSenescence is a persistent state of cell cycle arrest. Induction of senescence has been explored as a barrier against tumor progression and is used as a therapeutic option. Despite the advantages of the introduction of senescence‐inducing compounds in the clinic, recent studies show that their side‐effects can be partially masking their ...
Alejandra Estepa‐Fernández, María Alfonso, Ángela Morellá‐Aucejo, Alba García‐Fernández, Araceli Lérida‐Viso, Beatriz Lozano‐Torres, Irene Galiana, Paula M. Soriano‐Teruel, Félix Sancenón, Mar Orzáez, Ramón Martínez‐Máñez   +10 more
openaire   +1 more source

Senolysis and Senostasis Through the Plasma Membrane

2020
With increasing evidence that senescent cells are detrimental towards a range of age-associated diseases and physiologic declines, there is rising urgency to develop interventions to suppress their adverse effects. Most senolytic approaches aim to eliminate senescent cells by rendering them vulnerable to apoptosis, while senostatic (senomorphic ...
Kyoung Mi Kim, Ji Heon Noh, Myriam Gorospe   +2 more
openaire   +1 more source

A novel BRD4 degrader, ARV-825, attenuates lung fibrosis through senolysis and antifibrotic effect

Respiratory Investigation, 2023
Recent studies suggest that cellular senescence is related to the pathogenesis of idiopathic pulmonary fibrosis. However, cellular senescence has yet to be targeted therapeutically in clinical practice. ARV825, a recently developed BRD4 degrader, has been reported as a novel senolytic drug.
Seidai Sato, Kazuya Koyama, Hirohisa Ogawa, Kojin Murakami, Takeshi Imakura, Yuya Yamashita, Kozo Kagawa, Hiroshi Kawano, Eiji Hara, Yasuhiko Nishioka   +9 more
openaire   +2 more sources

A novel platform for precise senolysis

Mechanisms of Ageing and Development
The selective eradication of senescent cells using senolytic compounds represents a promising strategy to treat senescence-associated diseases like aging and cancer. However, many senolytics may cause systemic toxicity. Magkouta et al., writing in Nature Aging, introduced mGL392, an advanced senolytic platform utilizing a lipofuscin-binding domain ...
Conti, Anastasia, Di Micco, Raffaella
openaire   +2 more sources

Senolysis Enabled by Senescent Cell‐Sensitive Bioorthogonal Tetrazine Ligation

Angewandte Chemie International Edition
AbstractAlthough the clearance of senescent cells has been proven to slow down the aging process and promote anti‐cancer chemotherapy, the development of senolytics remains challenging. Herein, we report a senolytic strategy enabled by senescent cell‐sensitive bioorthogonal tetrazine ligation.
Mengyang Chang, Yue Dong, Hang Xu, Alexis B. Cruickshank‐Taylor, Jacob S. Kozora, Baran Behpour, Wei Wang   +6 more
openaire   +2 more sources

A cFLIP-flop switch for senolysis

Nature Cancer, 2022
Dorothy N. Y. Fan, Clemens A. Schmitt
openaire   +2 more sources