Results 171 to 180 of about 1,495 (185)

Senolysis through thrombomodulation

Cell Research, 2023
Corey M. Webster, Jan M. van Deursen
openaire   +2 more sources

Effects of triggers of senescence and senolysis in murine pancreatic cancer cells

Hepatobiliary & Pancreatic Diseases International
The combination of senescence triggers with senolytic drugs is considered a promising new approach to cancer therapy. Here, we studied the efficacy of the genotoxic agent etoposide (Eto) and irradiation in inducing senescence of Panc02 pancreatic cancer cells, and the capability of the Bcl-2 inhibitor navitoclax (ABT-263; Nav) to trigger senolysis ...
Denis, Revskij, Aline, Woitas, Bianca, Kölle, Camilla, Umstätter, Dietmar, Zechner, Faiz M, Khan, Georg, Fuellen, Robert, Jaster   +7 more
openaire   +2 more sources

Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies

Cell Death & Differentiation
Cellular senescence contributes to a variety of pathologies associated with aging and is implicated as a cellular state in which cancer cells can survive treatment. Reported senolytic drug treatments act through varying molecular mechanisms, but heterogeneous efficacy across the diverse contexts of cellular senescence indicates a need for predictive ...
Julie A. MacDonald, Gary A. Bradshaw, Fleur Jochems, René Bernards, Anthony Letai   +4 more
openaire   +2 more sources

THERAPEUTIC SENOLYSIS IMPROVES VASCULAR FUNCTION DURING DIABETIC RETINOPATHY

Canadian Journal of Cardiology, 2023
S. Crespo-Garcia, F. Fournier, R. Diaz-Marin, G. Cagnone, G. Blot, S. Klier, J. Joyal, A. Wilson, J. Dananberg, A. Ghosh, P. Tsuruda, P. Sapieha   +11 more
openaire   +1 more source

Senolysis by Targeting Metabolic Reprogramming in Senescent Lung Fibroblasts

A107. AGING AND LUNG DISEASES COMING TO AGE, 2023
G. Liu, H. Cui, N. Xie, S. Banerjee, R.-M. Liu, Y.Y. Sanders   +5 more
openaire   +1 more source

Senolysis of bleomycin-induced senescent vestibular schwannoma cells by navitoclax

2023
Trabajo presentado en Senestherapy-III: Cell senescence: mechanisms and therapies Meeting, celebrado el 07 de octubre de 2022.
openaire   +1 more source

Abstract 5342: Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells

Cancer Research
Abstract The cyclin D1-Cyclin-Dependent Kinases 4 and 6 (CDK4/6) complex is crucial for the development of melanoma. We previously demonstrated that targeting CDK4/6 using small molecule inhibitors (CDK4/6i) suppresses BrafV600E melanoma growth in vitro and in vivo through induction of cellular senescence.
Justin Kim, Bryce Brunetti, Ayanesh Kumar, Ankit Mangla, Kord Honda, Akihiro Yoshida   +5 more
openaire   +1 more source

New Senolysis Approach via Antibody–Drug Conjugate Targeting of the Senescent Cell Marker Apolipoprotein D for Skin Rejuvenation

International Journal of Molecular Sciences, 2023
Kento Takaya, Toru Asou, Kazuo Kishi
exaly  

Efficacy and limitations of senolysis in atherosclerosis

Cardiovascular Research, 2022
Anuradha Kaistha, Anna Uryga, Sebnem Oc
exaly  

Ouabain and chloroquine trigger senolysis of BRAF‐V600E‐induced senescent cells by targeting autophagy

Aging Cell, 2021
Valentin L'Hôte, Guillaume Pinna, Agnès Delaunay-Moisan   +2 more
exaly