Results 101 to 110 of about 6,153 (216)

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective

Annals of Medicine
Objective Cellular senescence is often linked to diseases or states of dysfunction, including reproductive disorders caused by ovarian dysfunction. It plays a significant role in conditions like polycystic ovary syndrome (PCOS).
Xin Xin, Li Dong, Jiaxi Li, Jinfu Zhang, Haicui Wu   +4 more
doaj   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Senesens. Heart. Senotherapy

Фармакокинетика и Фармакодинамика
Senescence — cellular aging — is a special form of cell death, characterized by the cell’s irreversible loss of its proliferation potential and the development of resistance to apoptosis.
S. A. Kryzhanovskii, M. B. Vititnova
doaj   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Cellular senescence in colorectal cancer: its occurrence, effect and therapy

Frontiers in Oncology
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Although the use of small molecule drugs or targeted drugs has shown significant efficacy in the treatment of CRC, the drug resistance after treatment and the high recurrence ...
Yabing Liang, Yabing Liang, Miao Wang, Xianjue Wang, Zhiqing Yang, Shucheng Wang, Fengyi Li, Liya Su, Ling Yang   +8 more
doaj   +1 more source

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley   +1 more source

SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY

Central Asian Journal of Medical Hypotheses and Ethics
Aging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev, Prim B. Singh
doaj   +1 more source

A Novel Peptide Targeting the USP25–SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence

Aging Cell, Volume 25, Issue 11, November 2026.
USP25‐mediated K63‐linked deubiquitination of SIRT1 at K506 and K513 suppresses its activity to promote senescence. These findings unveil a novel aging regulatory axis and identify a peptide targeting the USP25–SIRT1 interaction for anti‐senescence therapeutic intervention.
YuJuan Zhou, Xinshu Wang, Jiyuan Zhang, Hanqiong Qiang, Xinru Zhao, Jingyi Luo, Yanjun Ji, Jiakai Yao, Linhui Zhai, Tingting Zhang, Ke Li, Yuping Chen, Jian Yuan, Lei Li, Yunhui Li   +14 more
wiley   +1 more source

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Frontiers in Immunology
Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and non-autoimmune mediated.
Carolina Ferreira, Carolina Ferreira, Carolina Ferreira, Carolina Ferreira, Pedro Vieira, Pedro Vieira, Pedro Vieira, Pedro Vieira, Pedro Vieira, Helena Sá, Helena Sá, Helena Sá, João Malva, João Malva, João Malva, João Malva, Miguel Castelo-Branco, Miguel Castelo-Branco, Miguel Castelo-Branco, Flávio Reis, Flávio Reis, Flávio Reis, Flávio Reis, Sofia Viana, Sofia Viana, Sofia Viana, Sofia Viana, Sofia Viana   +27 more
doaj   +1 more source