Results 101 to 110 of about 6,461 (225)

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs. [PDF]

Molecules
The accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the limited number of known senolytics and the incomplete understanding of their mechanisms. This study
Li J, Zhao K, Yang G, Lv H, Zhang R, Li S, Chen Z, Xu M, Yang N, Dai S.   +9 more
europepmc   +3 more sources

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice [PDF]

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Baker, Jonathan R, Daly, Leah, Hassibi, Shyreen, Ito, Kazuhiro, Kimura, Genki, Kizawa, Yasuo, Nishimoto, Yuki   +6 more
core   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies [PDF]

A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely in their sensitivity ...
Alarcón Cor, Tomás, Bosch-Barrera, J, Cuyàs, Elisabet, Llop-Hernández, Àngela, Lupu, Ruth, López, Júlia, López-Bonet, Eugeni, Martin-Castillo, Begoña, Martínez Balibrea, Eva, Menendez, Javier A., Sardanyés, Josep, Serrano-Hervás, Eila, Teixidor, Eduard, Verdura, Sara   +13 more
core   +1 more source

Targeting senescent cells in translational medicine. [PDF]

, 2019
Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a ...
Doherty, Gary J, González-Gualda, Estela, Muñoz-Espín, Daniel, Paez-Ribes, Marta   +3 more
core   +2 more sources

CAR‐T Cells: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract outlines the current status, challenges, and future prospects of CAR‐T cells. The biological basis of CAR‐T cell therapy is the elegant redirection of adaptive immunity. Its initial successes have exposed a landscape of multifaceted challenges.
Aya Sedky Adly, Guillaume Cartron, Afnan Sedky Adly, Jean‐Christophe Egea, Pierre‐Yves Collart Dutilleul, Mahmoud Sedky Adly, Martin Villalba   +6 more
wiley   +1 more source

Diminished and Altered Cellular Senescence Response in Delayed Wound Healing of Aging

Aging Cell, Volume 25, Issue 5, May 2026.
Acute wound healing in young skin is supported by a transient population of senescent fibroblasts with proreparative, ECM‐remodeling functions. Aging disrupts both the induction and functional identity of these cells, contributing to delayed wound closure and impaired tissue repair.
Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Qiaoling Wang, Grace Haeun Shin, Jannat Dhillon, Daniel Sam Roh   +5 more
wiley   +1 more source

Senolytic Treatment With Fisetin Reverses Age‐Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12

Aging Cell, Volume 25, Issue 5, May 2026.
Single‐cell transcriptomics identifies that oral, intermittent fisetin supplementation improves endothelial function by targeting senescent endothelial cell‐derived senescence‐associated secretory phenotype (SASP) factors and CXCL12 in old animals. The SASP and specifically CXCL12 were found to drive age‐related endothelial dysfunction by promoting ...
Sophia A. Mahoney, Krystyna Mazan‐Mamczarz, Dimitrios Tsitsipatis, Nicholas S. VanDongen, Charnae’ Henry‐Smith, Ada N. Okereke, Rachel Munk, Sanna Darvish, Kevin O. Murray, Supriyo De, Myriam Gorospe, Douglas R. Seals, Matthew J. Rossman, Allison B. Herman, Zachary S. Clayton   +14 more
wiley   +1 more source