Results 101 to 110 of about 1,067 (186)

A Comparative Evaluation of Senolytics and Disease-Modifying Antirheumatic Drugs in Elderly Patients with Autoimmune Diseases

Introduction The study aims to evaluate whether senolytics, targeting senescent cells, are more effective than conventional Disease-modifying antirheumatic Drugs (DMARDs) in managing age-related autoimmune diseases.
Lijamol Varghese Thoppil, Nameera Zaheer Surve, Pooja Ranjith   +2 more
core   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Moving from an "anti-aging" paradigm toward the concept of "disease-free aging": the role of senolytics in modern medicine [PDF]

Senescent cells increase with aging and are related to the promotion of inflammation and neoplasia through the senescence-associated secretory phenotype (SASP). These cells are closely related to the biological aging process and, most importantly, to age-
Ivan Aprahamian, Aprahamian,Ivan, Moreira,Virgílio Garcia, Pain,Andréia, Andréia Pain, Virgílio Garcia Moreira   +5 more
core   +1 more source

The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chronic heart failure: rationale and study design

Российский журнал гериатрической медицины
RELEVANCE. Chronic heart failure (CHF) is an age-related disease affecting approximately 63 million people worldwide. In Russia, the prevalence of CHF has increased from 6.1 % to 8.2 % over the past 20 years, with most experts attributing this growth to ...
I. Sh. Daudov, A. G. Plisyuk, R. A. Abramovich, O. G. Potanina, A. G. Klementeva, Zh. A. Akopyan, A. Yu. Efimenko, Ya. A. Orlova   +7 more
doaj   +1 more source

Bioresorbable Scaffolds for Coronary Arteries: Where Do We Stand Today?

VIEW Medicine, Volume 1, Issue 1, August 2026.
Bioresorbable coronary scaffolds are moving from thick strut pitfalls to thinner, stronger, healing‐oriented designs. Integrating advances in materials, guided implantation with preparation, size, and postdilation steps, and resorption aligned to healing, we synthesize clinical evidence and chart a roadmap toward intelligent, transient platforms ...
Junya Matsuda, Tatsuya Watanabe, Satoshi Yuhara, John M. Kelly, Hirotsugu Kurobe, Toshiharu Shinoka   +5 more
wiley   +1 more source

Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiome

Frontiers in Microbiology
Type 2 diabetic osteoporosis (T2DOP) is a complex metabolic bone disorder characterized by reduced bone density and increased risk of osteoporosis in patients with type 2 diabetes mellitus. The etiology of T2DOP is multifactorial, involving hyperglycemia,
Junzheng Yang, Junzheng Yang, Junzheng Yang, Junzheng Yang, Hua Zhang, Zhuoxu Gu, Zhuoxu Gu, Zhuoxu Gu, Guanghui Zhou, Guanghui Zhou, Guanghui Zhou, Guihong Liang, Guihong Liang, Guihong Liang, Lingfeng Zeng, Lingfeng Zeng, Lingfeng Zeng, Jinlong Zhao, Jinlong Zhao, Jinlong Zhao, Weiyi Yang, Weiyi Yang, Weiyi Yang, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jianke Pan, Jianke Pan, Jianke Pan   +31 more
doaj   +1 more source