Results 111 to 120 of about 6,461 (225)

Cellular Senescence: The Driving Force of Musculoskeletal Diseases [PDF]

The aging of the world population is closely associated with an increased prevalence of musculoskeletal disorders, such as osteoporosis, sarcopenia, and osteoarthritis, due to common genetic, endocrine, and mechanical risk factors.
Angela Chiavoghilefu, Angela Falvino, Annalisa Botta, Beatrice Gasperini, Elena Gasbarra, Ida Cariati, Roberto Bonanni, Umberto Tarantino, Virginia Tancredi   +8 more
core   +1 more source

Histone Deacetylase 9 Gene Deletion Ameliorates Aging‐Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Cellular senescence and mitochondrial dysfunction disrupt adipose tissue homeostasis during aging, but mechanisms remain unclear. HDAC9 expression increases with age in mouse adipose tissue and Hdac9 knockout mice showed reduced fat mass, senescence markers, and enhanced mitochondrial gene expression, respiration, and thiosulfate sulfurtransferase (Tst)
Brandee Goo, Samah Ahmadieh, Praneet Veerapaneni, Hong Shi, David S. Kim, Mourad Ogbi, Ronnie Chouhaita, Nicole Cyriac, Stephen Cave, Lingling Liu, Yong Zhang, Quansheng Du, Ha Won Kim, Yun Lei, Xin‐Yun Lu, Neal L. Weintraub   +15 more
wiley   +1 more source

Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy

Pharmaceuticals
Background/Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the elderly. Cellular
Antonio Battaglia-Vieni, Vanessa Marchant, Lucia Tejedor-Santamaria, Cristina García-Caballero, Elena Flores-Salguero, María Piedad Ruiz-Torres, Sandra Rayego-Mateos, Ana Belen Sanz, Alberto Ortiz, Marta Ruiz-Ortega   +9 more
doaj   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions

Biomolecules
Cellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). While transient senescence
Timur Saliev, Prim B. Singh
doaj   +1 more source

Senolytic treatment for low back pain

Science Advances
Senescent cells (SnCs) accumulate because of aging and external cellular stress throughout the body. They adopt a senescence-associated secretory phenotype (SASP) and release inflammatory and degenerative factors that actively contribute to age-related diseases, such as low back pain (LBP). The senolytics, o
Mannarino, Matthew, Cherif, Hosni, Ghazizadeh, Saber, Martinez, Oliver Wu, Sheng, Kai, Cousineau, Elsa, Lee, Seunghwan, Millecamps, Magali, Gao, Chan, Gilbert, Alice, Peirs, Cedric, Naeini, Reza Sharif, Ouellet, Jean, S. Stone, Laura, Haglund, Lisbet   +14 more
openaire   +3 more sources

The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chronic heart failure: rationale and study design

Российский журнал гериатрической медицины
RELEVANCE. Chronic heart failure (CHF) is an age-related disease affecting approximately 63 million people worldwide. In Russia, the prevalence of CHF has increased from 6.1 % to 8.2 % over the past 20 years, with most experts attributing this growth to ...
I. Sh. Daudov, A. G. Plisyuk, R. A. Abramovich, O. G. Potanina, A. G. Klementeva, Zh. A. Akopyan, A. Yu. Efimenko, Ya. A. Orlova   +7 more
doaj   +1 more source

Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiome

Frontiers in Microbiology
Type 2 diabetic osteoporosis (T2DOP) is a complex metabolic bone disorder characterized by reduced bone density and increased risk of osteoporosis in patients with type 2 diabetes mellitus. The etiology of T2DOP is multifactorial, involving hyperglycemia,
Junzheng Yang, Junzheng Yang, Junzheng Yang, Junzheng Yang, Hua Zhang, Zhuoxu Gu, Zhuoxu Gu, Zhuoxu Gu, Guanghui Zhou, Guanghui Zhou, Guanghui Zhou, Guihong Liang, Guihong Liang, Guihong Liang, Lingfeng Zeng, Lingfeng Zeng, Lingfeng Zeng, Jinlong Zhao, Jinlong Zhao, Jinlong Zhao, Weiyi Yang, Weiyi Yang, Weiyi Yang, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jianke Pan, Jianke Pan, Jianke Pan   +31 more
doaj   +1 more source

Targeting zombie cells: Potential of senolytics in slowing aging and promoting longevity

Journal of the Pakistan Medical Association
Damaged cells known as senescent cells, are those that stop reproducing but keep being metabolically active, secreting harmful substances and consequently triggering the inflammation and damage of the surrounding cells.
Kainat Younis, Ayesha Younis, Hafsa Ahsun   +2 more
doaj   +1 more source

Beyond attenuation: a translational review of curative-intent pharmacological targets in idiopathic pulmonary fibrosis

Frontiers in Medicine
Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal lung disease with a median survival of 3–5 years, driven by a profound unmet medical need. The current standard-of-care agents, pirfenidone and nintedanib, merely slow disease progression and ...
Ghaith K. Mansour, Ahmad W. Hajjar, Hatouf H. Sukkarieh   +2 more
doaj   +1 more source