Results 111 to 120 of about 1,067 (186)

Cellular Heterogeneity During Arterial Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu, Paul‐Lennard Mendez, Dimitri Kasakovski, Judith Sluimer   +3 more
wiley   +1 more source

Identification of HSP90 inhibitors as a novel class of senolytics [PDF]

, 2017
Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased senescent cell burden in various tissues is a major contributor to aging and age-related diseases.
Corbo, Lana, Nadja Ring, Yi Zhu, Mauro Giacca, Laura J. Niedernhofer, Tchkonia, Tamara, Heike Fuhrmann-Stroissnigg, Jing Zhao, Jennifer L. Stripay, Ling, Yuan Yuan, Paul D. Robbins, Stripay, Jennifer L., Siobhan Q. Gregg, Fuhrmann-Stroissnigg, Heike, Kirkland, James L., Xuesen Li, Tamara Tchkonia, Robbins, Paul D., Dorronsoro, Akaitz, Niedernhofer, Laura J., Priscilla Tang, Li, Xuesen, Gregg, Siobhan Q., Ring, Nadja, Lana Corbo, James L. Kirkland, Zhu, Yi, Brooks, Robert W., Sara J. McGowan, Giacca, Mauro, Diego Grassi, Grassi, Diego, McGowan, Sara J., Tang, Priscilla, Akaitz Dorronsoro, Bukata, Christina, Christina Bukata, Zhao, Jing, Yuan Yuan Ling, Robert W. Brooks   +39 more
core   +1 more source

Beyond attenuation: a translational review of curative-intent pharmacological targets in idiopathic pulmonary fibrosis

Frontiers in Medicine
Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal lung disease with a median survival of 3–5 years, driven by a profound unmet medical need. The current standard-of-care agents, pirfenidone and nintedanib, merely slow disease progression and ...
Ghaith K. Mansour, Ahmad W. Hajjar, Hatouf H. Sukkarieh   +2 more
doaj   +1 more source

Sustained Hypoxia‐Inducible Factor 1‐Alpha Accumulation Disrupts the Articular Niche to Promote Osteoarthritis Pathogenesis

Aging Cell, Volume 25, Issue 7, July 2026.
Sustained HIF‐1α accumulation is not a compensatory shield, but a potent pathogenic driver of osteoarthritis. Continuous HIF‐1α signaling physically eradicates the avascular cartilage niche and primes the synovium for inflammation, establishing HIF‐1α as a critical target for disease‐modifying therapies.
Weiyuan Gong, Chu Tao, Xingyun Wang, Rongdong Liao, Jianglong Li, Xiongtian Guo, Minghao Qu, Jianmei Huang, Mingjue Chen, Fuxin Wei, Peng Wang, Lijun Lin, Di Chen, Qing Yao, Chunyi Wen, Guozhi Xiao   +15 more
wiley   +1 more source

Targeting zombie cells: Potential of senolytics in slowing aging and promoting longevity

Journal of the Pakistan Medical Association
Damaged cells known as senescent cells, are those that stop reproducing but keep being metabolically active, secreting harmful substances and consequently triggering the inflammation and damage of the surrounding cells.
Kainat Younis, Ayesha Younis, Hafsa Ahsun   +2 more
doaj   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Mechanisms and Clinical Manifestations of Age‐Related Impairment in Wound Healing

International Wound Journal, Volume 23, Issue 7, July 2026.
ABSTRACT Chronic wounds account for a considerable burden on the overall US healthcare system, affecting an estimated 10.2 million people and costing as much as $148 billion dollars in 2022 alone. Elderly patients suffer disproportionately, as nearly 85% of the chronic wound population is over the age of 65 years old.
Daniel A. Rabin, Tiffany Kim, Julia K. Kaniuk, Marlynn P. Lopez, Spencer Green, Aneeq S. Chaudhry, Katherine Kozlowski, Diana Griffin, Tarifa H. Adam, Thomas A. Mustoe, Robert D. Galiano   +10 more
wiley   +1 more source

Emerging use of senolytics and senomorphics against aging and chronic diseases

, 2020
© 2020 Wiley Periodicals LLC Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer.
Ko, Yun‐fei, Wu, Cheng‐yeu, Jan Martel, Perfettini, Jean‐luc, Voisin, Laurent, Young, John, Young, John D., Laurent Voisin, Wu, Cheng Yeu, David M. Ojcius, Peng, Hsin‐hsin, Ko, Yun Fei, Ojcius, David, Hsin‐Hsin Peng, Yun‐Fei Ko, Jean‐Luc Perfettini, Ojcius, David M., Perfettini, Jean Luc, John D. Young, Peng, Hsin Hsin, Martel, Jan, Cheng‐Yeu Wu   +21 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, Volume 7, Issue 2, Page 52-66, June 2026.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Metabolites
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
doaj   +1 more source