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Journal of Internal Medicine, Volume 300, Issue 5, Page 610-622, November 2026.Abstract Population ageing is portrayed as a threat to the sustainability of health and welfare systems. This narrative—grounded in static chronological definitions of old age—risks overstating the burden of increasing longevity while overlooking changes in survival, health and population composition. In this article, we adopt a demographic perspective
Daniele Vignoli +7 more
wiley +1 more source
Senolytics - current state [PDF]
, 2018 Cellular senescence is a state of the permanent cell cycle arrest caused by different stresses or cell to cell fusion. Senescent cells, unlike naturally aged cells, exhibit a specific phenotype, referred to as senescence associated phenotype (SASP).
Sekáč, Dávid
core
Advanced ScienceTargeting the limited therapeutic options and frequent drug resistance in triple negative breast cancer (TNBC) remains a critical clinical challenge.
Liya Yu +8 more
doaj +1 more source
BiomedicinesCellular senescence is a permanent cell cycle arrest that plays a critical role in the development and pathogenesis of age-related diseases. This paper aims to present the biological mechanisms of cellular senescence and the role of the senescence ...
Zuzanna Krupa +9 more
doaj +1 more source
Клинический разбор в общей медицинеBackground. The biggest risk factor for Alzheimer's disease (AD) is aging, contributing to impaired clearance of tau and amyloid-beta proteins, microglial senescence, endoplasmic reticulum stress, lipid dysregulation, and excitotoxicity.
Khaled A. Abdel-Sater
doaj +1 more source
Senotherapy: scientific advances and clinical potential of senolytic therapies
O Mundo da SaúdeSenotherapy represents an emerging therapeutic approach to combat deleterious senescent cells, whose pro-inflammatory accumulation contributes to various aging-associated pathologies. This study aimed to analyze and systematize recent scientific advances
Adriele Afonso Miranda +5 more
doaj +1 more source
, 2019 Aging is the most important single risk factor for many chronic diseases such as cancer, metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might, therefore, be a better strategy than targeting each chronic disease individually ...
Kang, Chanhee
core +1 more source
Targeting anxiety and senescence with senolytics
Aging, 2022 Raffaele, Marco, Vinciguerra, Manlio
openaire +2 more sources
From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications
CellsCellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial ...
Timur Saliev, Prim B. Singh
doaj +1 more source
Therapeutic Potential of Senolytics in Cardiovascular Disease [PDF]
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old.
Arthur HM +3 more
core +2 more sources