Results 131 to 140 of about 6,461 (225)

Senescence of skeletal stem cells and their contribution to age-related bone loss [PDF]

Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone ...
Elkjær, Anna Sofie, Fernandez-Guerra, Paula, Figeac, Florence, Jeromdesella, Shakespeare, Kassem, Moustapha, Kjær, Pernille Kirkegaard, Nørgård, Mikkel Ørnfeldt, Wölfel, Eva M.   +7 more
core   +1 more source

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases

Bioengineering
The process of aging exerts profound effects on various physiological systems, leading to the progression of chronic degenerative disorders and pathologies associated with advancing age.
Junying Wu, Xiuxing Liu, Yidan Liu, Wenru Su, Yehong Zhuo   +4 more
doaj   +1 more source

Apoptotic vesicle-mediated senolytics requires mechanical loading

Theranostics
Rationale: Mechanical force plays crucial roles in extracellular vesicle biogenesis, release, composition and activity. However, it is unknown whether mechanical force regulates apoptotic vesicle (apoV) production. Methods: The effects of mechanical unloading on extracellular vesicles of bone marrow were evaluated through morphology, size distribution,
Xue, Zhulin, Jiang, Yexiang, Meng, Bowen, Lu, Lu, Hao, Meng, Zhang, Yi, Shi, Songtao, Li, Zili, Mao, Xueli   +8 more
openaire   +2 more sources

Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression

JHEP Reports
Background & Aims: Senescence has been reported to have differential functions in cholangiocytes and hepatic stellate cells (HSCs) during human and murine cholestatic disease, being detrimental in biliary cells and anti-fibrotic in HSCs.
Mar Moreno-Gonzalez, Katherine Hampton, Paula Ruiz, Gemma Beasy, Falk SP. Nagies, Aimee Parker, James Lazenby, Caitlin Bone, Ane Alava-Arteaga, Meha Patel, Charlotte Hellmich, Pablo Luri-Martin, Ece Silan, Mark Philo, David Baker, Simon M. Rushbrook, Falk Hildebrand, Stuart A. Rushworth, Naiara Beraza   +18 more
doaj   +1 more source

Targeting anxiety and senescence with senolytics

Aging, 2022
Raffaele, Marco, Vinciguerra, Manlio
openaire   +2 more sources

Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer\u27s Disease [PDF]

Senescent cell accumulation contributes to the progression of age-related disorders including Alzheimer\u27s disease (AD). Clinical trials evaluating senolytics, drugs that clear senescent cells, are underway, but lack standardized outcome measures.
Barthelemy, Nicolas, Garbarino, Valentina R., He, Yingxin, Kautz, Tiffany F., Lopez-Cruzan, Marisa, Mathews, Julia, Melendez, Justin, Orr, Miranda E., Palavicini, Juan Pablo, Xu, Peng, Zhan, Bin   +10 more
core   +1 more source

Paradoxes of senolytics

Aging, 2018
openaire   +2 more sources

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment. [PDF]

Aging Cell
Kasamoto J, González J, Markov Y, Sehgal R, Lee E, Dwaraka VB, Smith R, Higgins-Chen AT.   +7 more
europepmc   +1 more source

Cellular senescence and metabolic aging in type 2 diabetes: mechanistic insights and translational implications. [PDF]

Front Endocrinol (Lausanne)
Syed AR, Aloti RA, Awad BJ, Alghoul WII, Hassan MAMSA, Kharoufeh A, Rangraze I.   +6 more
europepmc   +1 more source

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers. [PDF]

Aging Cell
Tripathi U, Suda M, Kulshreshtha V, Piatkowski BT, Palmer AK, Giorgadze N, Inman C, Gasek N, Xu M, Johnson KO, Pirtskhalava T, Chaib S, Langhi Prata LPG, Zhu Y, Kandhaya-Pillai R, Tullius SG, Wyles SP, Majji R, Yalamanchili HK, Allison DB, Tchkonia T, Kirkland JL.   +21 more
europepmc   +1 more source