Results 131 to 140 of about 1,067 (186)
, 2019 Aging is the most important single risk factor for many chronic diseases such as cancer, metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might, therefore, be a better strategy than targeting each chronic disease individually ...
Kang, Chanhee
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Towards healthy aging : the effect of senolytics on age-related diseases [PDF]
, 2020 Cellular senescence is a state of cell cycle arrest that takes place in response to damaging stimuli such as telomere shortening. Despite their short-term beneficial effects, senescent cells have been proven to accumulate during aging, contributing to a ...
Universitat Autònoma de Barcelona. Facultat de Biociències +1 more
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Controversies Surrounding Critical‐Size Defects: Influence of Age and Biological Characteristics
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 6, June 2026.ABSTRACT Critical‐size defects (CSDs) in craniofacial reconstruction refer to osseous gaps that fail to heal spontaneously, increasing the risk of neurological impairment and craniofacial dysmorphology. Despite decades of investigation, controversy still exists surrounding the definition of CSDs, with criteria varying across species, experimental ...
Andrew Nordlund +7 more
wiley +1 more source
Respirology, Volume 31, Issue 6, Page 561-577, June 2026.ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.This study illustrates that omega‐3 PUFAs with their receptor FFAR4 alleviate tubular senescence and fibrosis in aged and fibrotic kidneys. Furthermore, we indicate that tubular FFAR4 improves renal senescence via 15d‐PGJ2‐PPARγ‐Klotho signaling, and suppresses kidney fibrosis by senescent tubular cell‐driven fibroblast activation.
Letian Yang +9 more
wiley +1 more source
The Aging Microenvironment Shapes Angiogenic Remodeling in IBD‐Associated Colorectal Carcinogenesis
Aging Cell, Volume 25, Issue 6, June 2026.In IBD, chronic inflammation promotes cellular senescence across epithelial, stromal, endothelial, and immune compartments. The resulting SASP drives pathological angiogenesis, vascular dysfunction, hypoxia, and immune suppression, thereby facilitating progression from inflammation to dysplasia and colitis‐associated colorectal cancer.
Ruoshu Duan +4 more
wiley +1 more source
Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls [PDF]
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the cause of death in 40% of individuals over 65 years old.
Spyridopoulos I +4 more
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Therapeutic Potential of Senolytics in Cardiovascular Disease [PDF]
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old.
Arthur HM +3 more
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Aging Cell, Volume 25, Issue 6, June 2026.Senescent myoblasts exhibit dysregulated Akt/mTORC1 signalling. Antioxidants can alleviate this dysregulation, as well as other downstream senescent phenotypes. Moreover, prolonged antioxidant treatment can selectively induce cell death in senescent myoblasts, suggesting that these cells are more susceptible to reductive stress.
Vladimir Belhac +13 more
wiley +1 more source