Results 141 to 150 of about 1,067 (186)
The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs
The tumor microenvironment (TME) plays an essential role in tumor progression and in modulating tumor response to anticancer therapy. Cellular senescence leads to a switch in the cell secretome, characterized by the senescence-associated secretory ...
Oleg N. Demidov +5 more
core +1 more source
The Clinical Respiratory Journal, Volume 20, Issue 6, June 2026.Basal cells are expanded within the small airway epithelium in IPF. This change is associated with the severity of fibrosis and may participate in disease pathogenesis via SP1‐mediated senescence‐associated secretory phenotype (SASP). ABSTRACT Idiopathic pulmonary fibrosis is a progressive interstitial lung disease with limited treatment options and ...
Xiaoyan Wang +5 more
wiley +1 more source
The aging paradox of Cushing's syndrome: Stress without clear senescence?
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira +1 more
wiley +1 more source
Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira +9 more
wiley +1 more source
Moving senolytics closer to the clinic in IPF
eBioMedicine, 2023 Daniel Kramer +2 more
openaire +3 more sources
Exploring the Epitranscriptomic Response to Senolytics and Senomorphs in Cellular Models of Aging
In senescence that occurs with aging, cells stop dividing and initiate a pro-inflammatory program called the senescence associated secretory phenotype (SASP).
Benson, Emily
core