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The potential of Senolytics in transplantation
Mechanisms of Ageing and Development, 2021Older organs provide a substantial unrealized potential with the capacity to close the gap between demand and supply in organ transplantation. The potential of senolytics in improving age-related conditions has been shown in various experimental studies and early clinical trials. Those encouraging data may also be of relevance for transplantation.
Tomohisa Matsunaga +2 more
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Senolytics and the compression of late-life mortality
Experimental Gerontology, 2021 Senescent cells play an important role in mammalian ageing and in the etiology of age-related diseases. Treatment of mice with senolytics – drugs that selectively remove senescent cells – causes an extension of median lifespan but has little effect on ...
Axel Kowald
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International Journal of Molecular Sciences, 2023 Peri-implantitis is a disease that causes the detachment of orthodontic mini-implants. Recently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. Senescent cell-eliminating drugs, termed “senolytics&
Masato Nakagawa +2 more
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International Journal of Molecular Sciences, 2021 Various stresses latently induce cellular senescence that occasionally deteriorates the functioning of surrounding tissues. Nevertheless, little is known about the appearance and function of senescent cells, caused by the implantation of beta-tricalcium ...
Yoshitomo Honda +2 more
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The prompt to discover senolytics
Nature Reviews Molecular Cell BiologyJames L Kirkland, Kirkland James L
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Senolytics: Opening avenues in drug discovery to find novel therapeutics for Parkinson’s Disease
Drug Discovery Today, 2023 Aging is one of the major risk factors for most neurodegenerative disorders including Parkinson's disease (PD). More than 10 million people are affected with PD worldwide.
Violina Kakoty +2 more
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Obesity, Senescence, and Senolytics
2021Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent cells within adipose tissue and other organs.
Selim, Chaib +2 more
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Science Translational Medicine, 2020
Repurposing CAR T cells to target senescent cells ameliorates liver fibrosis and extends survival in mice with lung adenocarcinoma.
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Repurposing CAR T cells to target senescent cells ameliorates liver fibrosis and extends survival in mice with lung adenocarcinoma.
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A guide to senolytic intervention in neurodegenerative disease
Mechanisms of Ageing and Development, 2021Cellular senescence is a potential tumor-suppressive mechanism that generally results in an irreversible cell cycle arrest. Senescent cells accumulate with age and actively secrete soluble factors, collectively termed the 'senescence-associated secretory phenotype' (SASP), which has both beneficial and detrimental effects.
Suckwon Lee +5 more
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Senolytic Drugs: Implications for Clinical Practice
Advances in Gerontology, 2023The aging mechanisms study is one of the most important aims in the field of geroscience and clinical medicine. There has been a wide range of fundamental research data accumulated on this matter. The processes associated with regeneration capability decrease, age-related decline of cell proliferation and resilience are highlighted in vitro studies, as
A. K. Ilyushchenko +6 more
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