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The paradox of cellular senescence in prostate cancer: from tumor suppression to tumor promotion. [PDF]
Front OncolXing Y +6 more
europepmc +1 more source
Senolytic Treatment With Dasatinib and Quercetin Reshapes Influenza-Specific CD8 T Cell Responses During Infection in Aged, Vaccinated Mice. [PDF]
Aging CellCadar AN +10 more
europepmc +1 more source
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The potential of Senolytics in transplantation
Mechanisms of Ageing and Development, 2021Older organs provide a substantial unrealized potential with the capacity to close the gap between demand and supply in organ transplantation. The potential of senolytics in improving age-related conditions has been shown in various experimental studies and early clinical trials. Those encouraging data may also be of relevance for transplantation.
Tomohisa Matsunaga +2 more
exaly +3 more sources
Obesity, Senescence, and Senolytics
2021Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent cells within adipose tissue and other organs.
Selim, Chaib +2 more
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Chemo-Senolytic Therapeutic Potential against Angiosarcoma
Journal of Investigative Dermatology, 2023AbstractAngiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, one of the taxanes (genotoxic drugs), although it has a limited effect due to chemoresistance for prolonged treatment.
Xuebing Wang +8 more
openaire +2 more sources