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International Journal of Molecular Sciences, 2023 Peri-implantitis is a disease that causes the detachment of orthodontic mini-implants. Recently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. Senescent cell-eliminating drugs, termed “senolytics&
Yoshitomo Honda +2 more
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Recent Advances in the Discovery of Senolytics
Mechanisms of Ageing and Development, 2021 The demonstration in model organisms that cellular senescence drives aging and age-related diseases has led to widespread efforts to identify compounds able to selectively kill senescent cells, termed senolytics. Approaches used to identify senolytics include bioinformatic analysis of senescent cell anti-apoptotic pathways (SCAPs) for drug development ...
Laura Niedernhofer, Paul D Robbins
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Obesity, Senescence, and Senolytics
Handbook of Experimental Pharmacology, 2021Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent cells within adipose tissue and other organs.
Selim Chaib +2 more
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International Journal of Molecular Sciences, 2021 Various stresses latently induce cellular senescence that occasionally deteriorates the functioning of surrounding tissues. Nevertheless, little is known about the appearance and function of senescent cells, caused by the implantation of beta-tricalcium ...
Yoshitomo Honda +2 more
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The Prompt to Discover Senolytics
Nature Reviews Molecular Cell BiologyJames L. Kirkland
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Science Translational Medicine, 2020
Repurposing CAR T cells to target senescent cells ameliorates liver fibrosis and extends survival in mice with lung adenocarcinoma.
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Repurposing CAR T cells to target senescent cells ameliorates liver fibrosis and extends survival in mice with lung adenocarcinoma.
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Cellular senescence and senolytics: the path to the clinic
Nature Medicine, 2022Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can arise throughout the lifespan and, if persistent, can have deleterious effects on tissue function due ...
Selim Chaib +2 more
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Antidiabetic Effects of the Senolytic Agent Dasatinib
Mayo Clinic Proceedings, 2021To evaluate the antidiabetic effects of the senolytic agent dasatinib in older patients with type 2 diabetes mellitus.This retrospective cohort study included enterprise-wide Mayo Clinic patients using Informatics for Integrating Biology at the Bedside from January 1994 through December 2019.
Omid Salaami +5 more
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2020
Cellular senescence is a hallmark of aging because senescent cells (SnCs) accumulate with age and play a causative role in many age-related diseases. Selectively eliminating SnCs has been emerging as a new strategy for treating age-related diseases and extending healthspan. Small molecules that targeting different SnC anti-apoptotic pathways (SCAPs) to
Yonghan He +2 more
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Cellular senescence is a hallmark of aging because senescent cells (SnCs) accumulate with age and play a causative role in many age-related diseases. Selectively eliminating SnCs has been emerging as a new strategy for treating age-related diseases and extending healthspan. Small molecules that targeting different SnC anti-apoptotic pathways (SCAPs) to
Yonghan He +2 more
openaire +1 more source