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The prompt to discover senolytics
Nature Reviews Molecular Cell BiologyJames L Kirkland
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Senolytic Drugs: Implications for Clinical Practice
Advances in Gerontology, 2023The aging mechanisms study is one of the most important aims in the field of geroscience and clinical medicine. There has been a wide range of fundamental research data accumulated on this matter. The processes associated with regeneration capability decrease, age-related decline of cell proliferation and resilience are highlighted in vitro studies, as
A. K. Ilyushchenko +6 more
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Science Translational Medicine, 2020
Repurposing CAR T cells to target senescent cells ameliorates liver fibrosis and extends survival in mice with lung adenocarcinoma.
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Repurposing CAR T cells to target senescent cells ameliorates liver fibrosis and extends survival in mice with lung adenocarcinoma.
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2020
Cellular senescence is a hallmark of aging because senescent cells (SnCs) accumulate with age and play a causative role in many age-related diseases. Selectively eliminating SnCs has been emerging as a new strategy for treating age-related diseases and extending healthspan. Small molecules that targeting different SnC anti-apoptotic pathways (SCAPs) to
Yonghan He +2 more
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Cellular senescence is a hallmark of aging because senescent cells (SnCs) accumulate with age and play a causative role in many age-related diseases. Selectively eliminating SnCs has been emerging as a new strategy for treating age-related diseases and extending healthspan. Small molecules that targeting different SnC anti-apoptotic pathways (SCAPs) to
Yonghan He +2 more
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Gerosuppressive and Senolytic Nutrients
2021The aging process is intimately regulated by the contribution of interactions between genetic, epigenetic and environmental factors. Every individual is distinguished by a specific personal lifestyle, since conception, that influences the state of health, either leading to the preservation of a good state of health or accelerated aging trajectories ...
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Senolytic potential of Hsp90 inhibitors
Current Chemical Biology, 2020: Hsp90 chaperone is an encouraging target for the development of novel anticancer agents. The failure of Hsp90 inhibitors to get regulatory approval for the treatment of cancer is hindered due to toxicity, cost involved in their development and formulation issues.
Sayan Dutta Gupta, Cheol Ho Pan
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Senolytic therapy for Alzheimer’s disease
Nature Medicine, 2023Frank M, Longo, Stephen M, Massa
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Immune checkpoint inhibitors as senolytic agents
Cell Research, 2022Parminder Singh +2 more
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