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Insights into the therapeutic strategies for aging and aging-associated diseases. [PDF]

Signal Transduct Target Ther
Dong R, Wu Q, Kan J, Fu C, Sorrentino V, Chow A, Lei Y, Wu D, Xu Z, Du J, Huang D.   +10 more
europepmc   +1 more source

Pore-forming venoms as a senolytic strategy

Nature Aging
openaire   +2 more sources

Senolytics and the Compression of Late-Life Mortality

Experimental Gerontology, 2021
\ua9 2021. Senescent cells play an important role in mammalian ageing and in the etiology of age-related diseases. Treatment of mice with senolytics – drugs that selectively remove senescent cells – causes an extension of median lifespan but has little ...
Axel Kowald, Thomas B L Kirkwood
exaly   +7 more sources

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The Potential of Senolytics in Transplantation

Mechanisms of Ageing and Development, 2021
Older organs provide a substantial unrealized potential with the capacity to close the gap between demand and supply in organ transplantation. The potential of senolytics in improving age-related conditions has been shown in various experimental studies and early clinical trials. Those encouraging data may also be of relevance for transplantation.
Jasper Iske, Hao Zhou, Stefan G Tullius
exaly   +3 more sources