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Cellular senescence and senolytics: the path to the clinic
Nature Medicine, 2022Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can arise throughout the lifespan and, if persistent, can have deleterious effects on tissue function due ...
Selim Chaib +2 more
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Antidiabetic Effects of the Senolytic Agent Dasatinib
Mayo Clinic Proceedings, 2021To evaluate the antidiabetic effects of the senolytic agent dasatinib in older patients with type 2 diabetes mellitus.This retrospective cohort study included enterprise-wide Mayo Clinic patients using Informatics for Integrating Biology at the Bedside from January 1994 through December 2019.
Omid Salaami +5 more
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2020
Cellular senescence is a hallmark of aging because senescent cells (SnCs) accumulate with age and play a causative role in many age-related diseases. Selectively eliminating SnCs has been emerging as a new strategy for treating age-related diseases and extending healthspan. Small molecules that targeting different SnC anti-apoptotic pathways (SCAPs) to
Yonghan He +2 more
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Cellular senescence is a hallmark of aging because senescent cells (SnCs) accumulate with age and play a causative role in many age-related diseases. Selectively eliminating SnCs has been emerging as a new strategy for treating age-related diseases and extending healthspan. Small molecules that targeting different SnC anti-apoptotic pathways (SCAPs) to
Yonghan He +2 more
openaire +1 more source
Gerosuppressive and Senolytic Nutrients
2021The aging process is intimately regulated by the contribution of interactions between genetic, epigenetic and environmental factors. Every individual is distinguished by a specific personal lifestyle, since conception, that influences the state of health, either leading to the preservation of a good state of health or accelerated aging trajectories ...
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Senolytic therapy for Alzheimer’s disease
Nature Medicine, 2023Frank M, Longo, Stephen M, Massa
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Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology, 2023Alejandro Silva-Palacios +1 more
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