Results 201 to 210 of about 6,461 (225)

Recent advances in the discovery of senolytics

Mechanisms of Ageing and Development, 2021
Lei Zhang, Paul D Robbins, Laura J Niedernhofer   +2 more
exaly  

Senolytic helpers

Nature Reviews Cancer, 2019
openaire   +2 more sources

Dual Activated Senolytic Prodrug

We present the concept of a precise senolytic prodrug activated in a two-stepmanner, functioning as a chemical AND gate. This design ensures therelease of a cytotoxic agent exclusively in senescent cells thatsimultaneously exhibit two key hallmarks of senescence: increased β-D-galactosidase activity detectable at suboptimal pH ≈6 (the commonly ...
openaire   +1 more source

Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability

EBioMedicine, 2023
Anoop M Nambiar, Dean Kellogg, James L Kirkland   +2 more
exaly  

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans

EBioMedicine, 2022
Yi Zhu, Erin O Wissler Gerdes, Tamar Pirtskhalava   +2 more
exaly  

Fisetin: A senolytic drug

2021
Asma Shafique, Sumia Akram, Muhammad Mushtaq   +2 more
openaire   +1 more source

Senolytic Drugs

2019
Valeria Conti, Teresa Iannaccone, Amelia Filippelli   +2 more
openaire   +1 more source

Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease

Biogerontology, 2023
Alejandro Silva-Palacios, Mina Königsberg   +1 more
exaly  

Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

Journal of the American Chemical Society, 2023
Hyewon Chung, Ja-Hyoung Ryu
exaly  

Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice

Aging Cell, 2022
Cory M Dungan, Kevin A Murach, John J Mccarthy   +2 more
exaly