Results 121 to 130 of about 1,067 (186)

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Targeting anxiety and senescence with senolytics

Aging, 2022
Raffaele, Marco, Vinciguerra, Manlio
openaire   +2 more sources

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source

clinical translation: senolytics and anti-aging

This study investigates the current state of clinical translation pathways for senolytic therapeutics in anti-aging interventions, with a focus on identifying translational bottlenecks and advancing evidence-based implementation strategies. As senolytics—
Hok San Chau, Hankun Su
core   +1 more source

Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells?

Frontiers in Cell and Developmental Biology
Aging is characterized by gradual deterioration of organ or tissue function and its ability to maintain homeostasis of the different physiological processes.
Barbora Judita Kasperova, Barbora Judita Kasperova, Anna Cinkajzlova, Ludek Horvath, Petr Svoboda, Petr Svoboda, Martin Haluzik, Martin Haluzik, Sona Stemberkova Hubackova, Sona Stemberkova Hubackova   +9 more
doaj   +1 more source

Vicatia thibetica de Boiss Crude Polysaccharide Delay the Aging of the Heart and Kidneys

Food Bioengineering, Volume 5, Issue 2, Page 278-289, June 2026.
Vicatia thibetica de Boiss crude polysaccharide (VTCP) attenuates cardiorenal aging by reducing oxidative stress, suppressing inflammation, and alleviating fibrosis. In naturally aged mice, VTCP remodels the gut microbiota, enriching beneficial short‐chain fatty acid‐producing bacteria. We propose that VTCP protects the heart and kidneys via modulation
Daoxu Zhang, Chengyi Wu, Zhiyang Ding, Yunyu Hong, Yehan Lu, Kunpeng Zhou, Ruixuan Deng, Laijia Li, Chao Li, Yongcheng Yang, Conglong Xia, Jian Li, Wenwen Liu, Faliang An, Zelan Hu   +14 more
wiley   +1 more source

Internship Reports and Monograph “Senolytics and Senomorphics for the Treatment of Osteoarthritis”

, 2021
Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de FarmáciaRealizado no âmbito da Unidade Curricular “Estágio Curricular” do Mestrado Integrado em Ciências Farmacêuticas da Faculdade de Farmácia da ...
Paz, Mariana Domingues
core  

Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases

Molecular Neurodegeneration, 2022
Sharyn L. Rossi, Preeti Subramanian, Guojun Bu, Adriana Di Polo, Todd E. Golde, Diane E. Bovenkamp   +5 more
doaj   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science
Aging is marked by the accumulation of cells expressing the cyclin‐dependent kinase inhibitor p16Ink4a. These p16⁺ cells, largely senescent, contribute to inflammation and tissue dysfunction. While eliminating p16⁺ cells improves healthspan, sex‐specific
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
doaj   +1 more source

Solanesol Alleviates Perfluoroheptanoic Acid‐Induced Premature Senescence in Human Skin Fibroblasts via RNA Methylation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu, Tingting Huang, Guisong Li, Xinyu Zhang, Luyi Tan, Chenyu Zhu, Wenji Zhang, Wenjuan Zhang   +7 more
wiley   +1 more source