Results 121 to 130 of about 6,461 (225)

The senotherapeutic potential of phytochemicals for age-related intestinal disease [PDF]

During the last few decades, life expectancy has increased worldwide along with the prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or “inflammaging”) appear to be connected to gut ...
Costa, Célia Maria, Kirkland, James L, Madureira, Raquel, Pedrosa, Sílvia Santos, Reis, Flávio   +4 more
core   +1 more source

Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications [PDF]

Cellular senescence; Prostate cancer; Senescence-associated secretory phenotypeSenescència cel·lular; Càncer de pròstata; Fenotip secretor associat a la senescènciaSenescencia celular; Cáncer de próstata; Fenotipo secretor asociado a la ...
Bacca, Luisa, Brandariz, Julian, Labbé, David, Mateo, Joaquin, Zacchi, Francesca, Zivi, Andrea   +5 more
core   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science
Aging is marked by the accumulation of cells expressing the cyclin‐dependent kinase inhibitor p16Ink4a. These p16⁺ cells, largely senescent, contribute to inflammation and tissue dysfunction. While eliminating p16⁺ cells improves healthspan, sex‐specific
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
doaj   +1 more source

Mechanisms of Senescence and Anti-Senescence Strategies in the Skin

Biology
The skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage.
Evangelia Konstantinou, Eliane Longange, Gürkan Kaya   +2 more
doaj   +1 more source

Senolytic CAR T cells [PDF]

Nature Medicine, 2020
openaire   +2 more sources

Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases

Molecular Neurodegeneration, 2022
Sharyn L. Rossi, Preeti Subramanian, Guojun Bu, Adriana Di Polo, Todd E. Golde, Diane E. Bovenkamp   +5 more
doaj   +1 more source

Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics. [PDF]

Lower urinary tract dysfunction (LUTD) increases with aging. Ensuing symptoms including incontinence greatly impact quality of life, isolation, depression, and nursing home admission.
Al-Naggar, Iman M, Antony, Maria, Baker, Dylan, Fraser, Matthew O, Godoy, Lucas Da Cunha, Kuchel, George A, Kuo, Chia-Ling, Smith, Phillip P, Wang, Lichao, Xu, Ming   +9 more
core   +2 more sources

Immune cell senescence in autoimmunity: implications for disease pathogenesis and therapeutic targeting

Frontiers in Immunology
The senescence of immune cells has also emerged as a key hallmark of immunological dysregulation and chronic inflammation in autoimmunity. Senescent immune cells are irreversibly arrested in the cell cycle, exhibit antimetabolic characteristics, and ...
Fei Yin, Yangfang He, Jian Li, Yuan Gao
doaj   +1 more source

Examining the effects of quercetin on phenotypic characteristics of human mesenchymal stem cells [PDF]

Introduction A significant obstacle to mesenchymal stem cell (MSC) potency and therapeutic utility is in vitro senescence, an irreversible cessation of replication associated with age-related complications.
Needy, Thomas M
core   +3 more sources

Senolytic Interventions for Type 2 Diabetes: Current Evidence and Future Directions

Diabetology
Cellular senescence, a phenomenon characterized by the accumulation of dysfunctional, metabolically active cells, is increasingly recognized to be a key player in aging-related metabolic disorders.
Selene Sodini, Milton Fabián Suarez-Ortegón   +1 more
doaj   +1 more source