Results 91 to 100 of about 1,067 (186)

Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells

, 2022
Background Fibro‐adipogenic progenitors (FAPs) in the muscles have been found to interact closely with muscle progenitor/stem cells (MPCs) and facilitate muscle regeneration at normal conditions.
Zewei Sun, Ying Li, Johnny Huard, William S. Hambright, Lei Liu, Xianlin Yue, Xiaodong Mu, Paul D. Robbins, Yan Cui, George Rodney, Zhihui Wang, Polina Matre, Jianming Wei   +12 more
core   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics

, 2022
A first-line therapeutic for high-grade glioma, notably glioblastoma (GBM), is the DNA methylating drug temozolomide (TMZ). Previously, we showed that TMZ induces not only apoptosis and autophagy, but also cellular senescence (CSEN).
Kaina, Bernd, Christmann, Markus, Beltzig, Lea, Bernd Kaina, Lea Beltzig, Markus Christmann   +5 more
core   +1 more source

Junctional Adhesion Molecule‐A (JAM‐A) Associates With High‐Risk Disease in Multiple Myeloma Patients and a Structure‐Based Rationally‐Designed Peptide Inhibitor Attenuates Tumorigenic Features In Vitro and In Vivo

European Journal of Haematology, EarlyView.
ABSTRACT Multiple myeloma (MM) is an incurable malignancy of terminally‐differentiated plasma cells that represents a major clinical challenge despite unprecedented therapeutic advances, particularly for patients with cytogenetically‐defined high‐risk MM (HR‐MM).
Niamh McAuley, Roisin McAvera, Dimitri Bong, Lara Donnelly, Izabela Cymer, Marian Brennan, Joanna Fay, Lance Hudson, John Quinn, Siobhan V. Glavey, Ann M. Hopkins   +10 more
wiley   +1 more source

Senolytics and their clinical potential

, 2018
Senolytics bieten die Möglichkeit einer neuen Behandlungsmethode für altersbedingte Erkrankungen, viele mit schlechten Prognosen und eingeschränkten Therapiemöglichkeiten wie Osteoporose, Lebersteatose oder Lungenfibrose.
Riemer, Natalie Mathab
core  

Deletion of SA β-Gal+ Cells Using Senolytics Improves Muscle Regeneration in Old Mice

, 2021
Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole-body metabolism, but their role in tissue reparative processes is incompletely understood.
Murach, Kevin A., Charlotte A. Peterson, Christopher S. Fry, Christopher J. Zdunek, Zdunek, Christopher J., Brightwell, Camille R., Tang, Zuo Jian, Davis A. Englund, Michael Franti, Antonio Filareto, Filareto, Antonio, Zachary Hettinger, Zheng Liu, Franti, Michael, Englund, Davis A., Kevin A. Murach, Zuo Jian Tang, Dungan, Cory M., Hettinger, Zachary, Cory M. Dungan, VonLehmden, Georgia L., Fry, Christopher S., Georgia L. Nolt, Camille R. Brightwell, Peterson, Charlotte A., Liu, Zheng   +25 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

TARGETING CHEMOTHERAPY-INDUCED SENESCENT HNSCC WITH SENOLYTICS

, 2022
TARGETING CHEMOTHERAPY-INDUCED SENESCENT HNSCC WITH SENOLYTICS Head and Neck squamous cell carcinoma (HNSCC) are cancers derived from the mucosal membranes of the oral cavity, larynx and pharynx. Cisplatin, a chemotherapeutic DNA damaging agent used in
Nguyen, Khanh T
core   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Establishing alamarBlue as a test method for potential senolytics

, 2018
Unsere alternde Gesellschaft und ihre Anforderungen machen Altersforschung notwendig. Eine Möglichkeit sind seneszente Zellen und Senolytics als neue Therapie, aber auch für die Grundlagenforschung von Alterungsprozessen.
Riemer, Natalie Mathab
core