Results 91 to 100 of about 6,461 (225)

Sex, senescence, senolytics, and cognition

Frontiers in Aging Neuroscience
This review focuses on sexual dimorphism in cellular senescence and senolytic treatment in relation to brain health and age-related cognitive decline. The stressors of aging, DNA damage, inflammation, and oxidative stress induce cell senescence, a hallmark of aging.
Thomas C. Foster, Thomas C. Foster, Ashok Kumar   +2 more
openaire   +3 more sources

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

European Journal of Medical Research
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Shangkun Zhao, Zhi Qiao, Roman Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu   +8 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Cells
Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial ...
Timur Saliev, Prim B. Singh
doaj   +1 more source

Cellular Senescence in Lung Cancer: Molecular Mechanisms and Therapeutic Interventions. [PDF]

Lung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases.
Adhikari, R, Bhattacharya, K, De Rubis, G, Devkota, SR, Dua, K, Gupta, G, Hansbro, PM, Jha, LA, Jha, SK, Mehndiratta, S, Panth, N, Paudel, KR, Singh, SK, Zhang, Y   +13 more
core   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Cholesterol accumulation promotes photoreceptor senescence and retinal degeneration [PDF]

PURPOSE: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD. Cellular senescence contributes to the development of numerous age-associated diseases.
Apte, Rajendra S, Colasanti, Jason, Lee, Tae Jun, Lin, Joseph B, Pfeifer, Charles W, Santeford, Andrea, Sohn, Brian S, Terao, Ryo, Yamaguchi, Shinobu, Yamamoto, Taku, Yoshida, Mitsukuni   +10 more
core   +2 more sources

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Senolytic treatment alleviates doxorubicin‐induced chemobrain

Aging Cell
AbstractDoxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced cognitive impairments (chemobrain). Chemobrain is associated with inflammation and oxidative stress similar to aging. As such, Dox treatment has also been used as a model of aging.
Vivekananda Budamagunta, Ashok Kumar, Asha Rani, Sahana Manohar Sindhu, Yang Yang, Daohong Zhou, Thomas C. Foster   +6 more
openaire   +2 more sources

Exploring the Intersections of Immunosenescence and Cellular Senescence in Health and Disease [PDF]

This thesis provides a comprehensive investigation into the role of cellular senescence in immune cells, focusing on macrophages and microglia in aging, diseases, and therapeutic responses, as well as the immune landscape during COVID-19.
Melo, Letícya
core   +1 more source