Results 91 to 100 of about 6,153 (216)

Moving from an "anti-aging" paradigm toward the concept of "disease-free aging": the role of senolytics in modern medicine [PDF]

Senescent cells increase with aging and are related to the promotion of inflammation and neoplasia through the senescence-associated secretory phenotype (SASP). These cells are closely related to the biological aging process and, most importantly, to age-
Ivan Aprahamian, Aprahamian,Ivan, Moreira,Virgílio Garcia, Pain,Andréia, Andréia Pain, Virgílio Garcia Moreira   +5 more
core   +2 more sources

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Sex, senescence, senolytics, and cognition

Frontiers in Aging Neuroscience
This review focuses on sexual dimorphism in cellular senescence and senolytic treatment in relation to brain health and age-related cognitive decline. The stressors of aging, DNA damage, inflammation, and oxidative stress induce cell senescence, a hallmark of aging.
Thomas C. Foster, Thomas C. Foster, Ashok Kumar   +2 more
openaire   +3 more sources

Telomere dysfunction is associated with exacerbated intermittent hypoxia-induced cognitive deficits and nerve damage

Frontiers in Aging Neuroscience
Cognitive impairment associated with obstructive sleep apnea (OSA) is more prevalent and severe in the elderly, possibly due to age-related increases in neuronal susceptibility to intermittent hypoxia (IH).
Ying Guo, Yuyang Miao, Yuyang Miao, Jin Tan, Jin Tan, Rui Zhao, Rui Zhao, Duo Jiang, Minghui Zou, Feng Wang, Feng Wang, Qiang Zhang, Qiang Zhang   +12 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Senolytic effects of a modified Gingerenone A

npj Aging
Abstract Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases.
Moaddel, Ruin, Sanehira, Chad, Keyes, Gregory, Cui, Chang-Yi, Ahmadkhaniha, Reza, Candia, Julián, Price, Nathan L., Eckroth, Sarah, Middleton, Bryce, Khadeer, Mohammed, Mazucanti, Caio H., McDevitt, Ross A., Gorospe, Myriam, de Cabo, Rafael, Egan, Josephine M., Ramsden, Christopher E., Ferrucci, Luigi   +16 more
openaire   +2 more sources

Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy

Current Issues in Molecular Biology
Cellular senescence is an irreversible cell cycle arrest, triggered by stressors like telomere shortening, DNA damage, and oncogenic signaling. These cells, often referred to as ‘zombie cells’ because they cease dividing yet resist apoptosis, drive the ...
Steven Januar Kusmanto
doaj   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐Senolytics

Advanced Healthcare Materials
AbstractCellular senescence is a significant risk factor for aging and age‐related diseases (ARD). The canonical senolytics Dasatinib and Quercetin (DQ) have shown promise in clearing senescent cells (SnCs); however, the lack of selectivity poses a challenge in achieving optimal outcomes.
Hairui Zhang, Xiaoling Xu, Xin Shou, Wucan Liao, Chengkang Jin, Changjiang Chen, Chen Zhang, Wenhua Gao, Junfeng Zhang, Weihong Ge, Liyun Shi   +10 more
openaire   +2 more sources

The Emerging Role of Senolysis in Atherosclerosis

Medicina
Atherosclerosis, a major contributor to vascular damage and plaque formation, is brought on by cellular senescence and chronic inflammation. A crucial matter that emerges is the classification of the disease in order to understand the pathogenic ...
Sylvia Vagena, Giorgos Theocharous, Alexios Theodorou, Pavlos Pantelis, Miltiadis Gravanis, Linnea Tscheuschner, Andreas Theodorou, George Galyfos, Frangiska Sigala, Nefeli Lagopati, Athanassios Kotsinas   +10 more
doaj   +1 more source