Results 161 to 170 of about 1,457 (176)

Emerging use of senolytics and senomorphics against aging and chronic diseases

Medicinal Research Reviews, 2020
AbstractSenescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age‐related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary ...
Jan Martel, David M. Ojcius, Cheng‐Yeu Wu, Hsin‐Hsin Peng, Laurent Voisin, Jean‐Luc Perfettini, Yun‐Fei Ko, John D. Young   +7 more
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Exploring the fuzzy border between senolytics and senomorphics with chemoinformatics and systems pharmacology

Biogerontology, 2022
Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Kevin Samael Olascoaga-Del Angel, Humberto Gutierrez, Mina Königsberg, Jaime Pérez-Villanueva, Norma Edith López-Diazguerrero   +4 more
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Senomorphic properties of miR-181b in aged human aortic smooth muscle cells

Physiology, 2023
Introduction: Age associated large artery stiffness (LAS) is an independent predictor of adverse cardiovascular health outcomes in humans and has also been shown to be associated with the development of heart failure, kidney disease, and even dementia.
Denisse Moreno, Venkateswara Gogulamudi, Lisa Lesniewski, Steven An, Anthony Donato, Eric Tuday   +5 more
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Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction

2023
The accumulation of senescent cells in the aging individual is associated with an increase in the occurrence of age-associated pathologies that contribute to poor health, frailty, and mortality. The number and type of senescent cells is viewed as a contributor to the body's senescence burden.
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Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

Free Radical Biology and Medicine, 2021
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Lagoumtzi, Sofia M, Chondrogianni, Niki
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Senomorphic, senolytic, and rejuvenation therapies

2022
Xiang Yang Zhu, Lilach O. Lerman
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HYDROCHLOROTHIAZIDE AS A NEW SENOMORPHIC DRUG CANDIDATE

Amaç: Konvansiyonel kanser tedavisinde kullanılan kemoterapötiklerin hem kanser hem de kanser olmayan hücrelerde hücresel senesensi indüklediği bilinmektedir. Senesent hücrelerin önemli özellikleri, hücre morfolojilerinde belirgin değişikliklerin olması ve bu hücrelerden senesens ilişkili sekretuvar fenotip (SASP) olarak adlandırılan çeşitli sitokin ...
Şimay Demir, Yaprak Dilber, Akgül, Senem   +1 more
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Combating Atherosclerosis with Chirality/Phase Dual‐Engineered Nanozyme Featuring Microenvironment‐Programmed Senolytic and Senomorphic Actions

Advanced Materials
AbstractSenescence plays a critical role in the development and progression of various diseases. This study introduces an amorphous, high‐entropy alloy (HEA)‐based nanozyme designed to combat senescence. By adjusting the nanozyme's composition and surface properties, this work analyzes its catalytic performance under both normal and aging conditions ...
Chengjin Ding, Jiao Min, Yongkang Tan, Liuting Zheng, Ruxuan Ma, Ruyi Zhao, Huiyue Zhao, Qingqing Ding, Hongshan Chen, Da Huo   +9 more
openaire   +2 more sources