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Therapeutic implications of senotherapy in neurodegenerative diseases: from molecular basis to clinical perspectives

Pharmacotherapy in Psychiatry and Neurology
Cezary Mydlak, Krzysztof Książek
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Spatially Confined Intervention of Cellular Senescence by a Lysosomal Metabolism Targeting Molecular Prodrug for Broad-Spectrum Senotherapy.

Angewandte Chemie, 2022
Specific intervention of senescent cells (SnCs) is emerging as a powerful means to counteract aging and age-related diseases. Canonical methods are generally designed to target SnC-associated signaling pathways, which are however dynamically changing and
Yanlan Liu, Yin-Zheng Xia, Jili Li, Linlin Wang, Xiyuan Luo, Yuqi Xie   +5 more
semanticscholar   +1 more source

"Senotherapy as a multitarget intervention in chronic obesity: Modulation of senescence, neuroinflammation, dysbiosis, and synaptic integrity in middle-aged female Wistar rats".

Experimental Neurology
The Obesity pandemic is a global health problem that has been reported to be more prevalent in women than in men. Obesity is a risk factor for numerous diseases and has recently been related to deficits in memory and learning processes.
R. P. Flores-Torres, Verónica Salas-Venegas, Roberto Santín-Márquez, Marisol De la Vega-Tinajar, R. J. Ramírez-Carreto, R. Librado-Osorio, A. Luna-López, A. Alarcón-Aguilar, N. López-Díazguerrero, Sofía Morán-Ramos, A. Chavarría, Beatriz Gómez-González, Mina Königsberg   +12 more
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[Senotherapy: Advances and new clinical perspectives].

Medecine sciences : M/S, 2021
Cellular senescence has been now shown to be at the root of many degenerative processes that characterize ageing. Thus, in addition to an irreversible proliferative arrest following various stresses or inappropriate stimuli, cellular senescence leads to genetic, epigenetic, metabolic, structural and functional adaptations of the cell.
Damien, Veret, Jean-Marc, Brondello
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Cardioprotective effect of senotherapy in chronically obese middle-aged female rats may be mediated by a MERCSs/Nrf2 interaction.

Journal of Nutritional Biochemistry
Hypercaloric intake promotes the development of obesity, a risk factor for cardiovascular disease (CVD). In recent years, it has been suggested that senescent cells have negative implications for the outcome of these chronic pathologies, and senotherapy ...
A. Silva-Palacios, A. Zúniga-Muñoz, E. Soria-Castro, Edith Álvarez-León, Mario Nieto, Gabriela Navarrete-Anastasio, Roxana Carbó, W. García-Niño, Paola Stephanie López-Cervantes, Verónica Salas-Venegas, R. P. Flores-Torres, A. Luna-López, Cecilia Zazueta, Mina Königsberg   +13 more
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S121 Effect of a novel senotherapy, geraldol, on cellular senescence markers in epithelial cells

New insights in COPD pathogenesis
K. Najafi, P. Fenwick, J. Devulder, P. Barnes, L. Donnelly   +4 more
semanticscholar   +2 more sources

The use of betaine as a novel senotherapy

Background: The global population demographic comprising those aged 65 years and over is increasing. Despite an increase in human life expectancy over the past 150 years, this has not been matched by a similar increase in health span (i.e. years of disease free living).
Ngoc Uyen Tran
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Advances in Senotherapies

2018
Aging brings about many risks factors that can lead to age-related chronic disorders such as atherosclerosis, osteoporosis, and neurodegenerative diseases. Implicated in aging and age-related pathologies, the accumulation of senescent cells can prevent tissue repair and regeneration, leading to loss of physiological function.
Janice Wong, Anam Qudrat, Abdullah Al Mosabbir, Kevin Truong   +3 more
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Senotherapy for attenuation of cellular senescence in aging and organ implantation

Journal of Industrial and Engineering Chemistry, 2017
Abstract Cellular senescence in transplant is induced by aging and therapy-induced stress, which is caused by generation of senescent cells in transplant during engraftment. These senescent cells induce transplant failure due to secretion of senescence-associated secretory phenotype (SASP).
D. Kang, Yeongwon Park, Dong Yun Lee
semanticscholar   +2 more sources

Senotherapy: A New Horizon for COPD Therapy.

Chest, 2021
There is increasing evidence that COPD is a disease of accelerated lung aging, with the accumulation of senescent cells that lose their ability to repair and secrete multiple inflammatory proteins known as the senescence-associated secretory phenotype (SASP), which mimic the profile of inflammatory mediators secreted in COPD.
Jonathan R, Baker, Louise E, Donnelly, Peter J, Barnes   +2 more
openaire   +1 more source